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    TOP2A DNA topoisomerase II alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700707, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TOP2Aprovided by VGNC
    Official Full Name
    DNA topoisomerase II alphaprovided by VGNC
    Primary source
    VGNC:VGNC:78620
    See related
    Ensembl:ENSMMUG00000008941
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TOP2A in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (51540255..51571945, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (46212392..46244240, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor alpha Neighboring gene gap junction protein delta 3 Neighboring gene insulin like growth factor binding protein 4 Neighboring gene tensin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in apoptotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 2-alpha
    Names
    DNA topoisomerase 2-alpha-like
    DNA topoisomerase II, alpha isozyme
    topoisomerase (DNA) II alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      51540255..51571945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015119588.2 → XP_014975074.1  DNA topoisomerase 2-alpha isoform X1

      UniProtKB/TrEMBL
      F7EVJ4, F7EVK2, H9YVX9
      Related
      ENSMMUP00000011731.4, ENSMMUT00000012509.4
      Conserved Domains (8) summary
      cd03365
      Location:455 → 575
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00187
      Location:711 → 1174
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:265 → 417
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:25 → 1497
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:80 → 185
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:1435 → 1521
      DTHCT; DTHCT (NUC029) region
      pfam15323
      Location:1357 → 1464
      Ashwin; Developmental protein
      pfam16898
      Location:573 → 711
      TOPRIM_C; C-terminal associated domain of TOPRIM

    2. XM_015119589.2 → XP_014975075.1  DNA topoisomerase 2-alpha isoform X2

      Conserved Domains (8) summary
      cd03365
      Location:443 → 563
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00187
      Location:699 → 1162
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      cd03481
      Location:253 → 405
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:13 → 1485
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam02518
      Location:68 → 173
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      pfam08070
      Location:1423 → 1509
      DTHCT; DTHCT (NUC029) region
      pfam15323
      Location:1345 → 1452
      Ashwin; Developmental protein
      pfam16898
      Location:561 → 699
      TOPRIM_C; C-terminal associated domain of TOPRIM
    Nucleotide Protein
    Heading Accession and Version

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