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    rgg2 quorum-sensing system transcriptional regulator Rgg2 [ Streptococcus pyogenes ]

    Gene ID: 69901277, updated on 6-Jun-2024

    Summary

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    Gene symbol
    rgg2
    Gene description
    quorum-sensing system transcriptional regulator Rgg2
    Locus tag
    DQM35_RS06965
    Gene type
    protein coding
    Organism
    Streptococcus pyogenes (strain: NCTC12064, serovar: Lancefield Group A, culture-collection: NCTC:12064)
    Lineage
    Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
    Old locus tag
    NCTC12064_01380
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    Genomic context

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    Location:
    chromosome: 1

    1 - NZ_LS483338.1Genomic Context describing neighboring genes Neighboring gene helicase HerA-like domain-containing protein Neighboring gene dephospho-CoA kinase Neighboring gene DNA-formamidopyrimidine glycosylase Neighboring gene hypothetical protein Neighboring gene peptide pheromone SHP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_LS483338.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond. Wilkening RV, et al. J Biol Chem, 2017 Dec 15. PMID 29030429, Free PMC Article
    2. Inactivation of the Rgg2 transcriptional regulator ablates the virulence of Streptococcus pyogenes. Zutkis AA, et al. PLoS One, 2014. PMID 25486272, Free PMC Article
    3. Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay. Capodagli GC, et al. Proc Natl Acad Sci U S A, 2020 Sep 29. PMID 32907945, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    quorum-sensing system transcriptional regulator Rgg2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_LS483338.1 Reference assembly

      Range
      1359401..1360267 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_002990747.1 quorum-sensing system transcriptional regulator Rgg2 [Streptococcus pyogenes]

      See identical proteins and their annotated locations for WP_002990747.1

      UniProtKB/TrEMBL
      A0A0E1ETS6, A0A0H2UTJ6, A0A0H3BX60, A0A4Q1QYJ2, Q1JN05, Q48UU7, Q490E3, Q9A132, U2W2H2
      Conserved Domains (2) summary
      cd00093
      Location:6 → 62
      HTH_XRE; Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.
      TIGR01716
      Location:66 → 274
      RGG_Cterm; transcriptional activator, Rgg/GadR/MutR family, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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