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    GHR growth hormone receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697986, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GHRprovided by VGNC
    Official Full Name
    growth hormone receptorprovided by VGNC
    Primary source
    VGNC:VGNC:72922
    See related
    Ensembl:ENSMMUG00000001336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GHR in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (42354116..42668444)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (43085181..43437062)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial-like Neighboring gene F-box protein 4 Neighboring gene zinc finger protein 35 pseudogene Neighboring gene uncharacterized LOC114678777 Neighboring gene plasminogen activator inhibitor 1 RNA-binding protein pseudogene Neighboring gene uncharacterized LOC114678778 Neighboring gene coiled-coil domain containing 152 Neighboring gene selenoprotein P

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monkey growth hormone (GH) receptor gene expression. Evidence for two mechanisms for the generation of the GH binding protein. Martini JF, et al. J Biol Chem, 1997 Jul 25. PMID 9228076
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of growth hormone receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth hormone receptor
    Names
    GH receptor
    somatotropin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042667.1 → NP_001036132.1  growth hormone receptor precursor

      See identical proteins and their annotated locations for NP_001036132.1

      Status: PROVISIONAL

      Source sequence(s)
      U84589
      UniProtKB/Swiss-Prot
      P79194
      UniProtKB/TrEMBL
      G7MV63
      Related
      ENSMMUP00000059083.1, ENSMMUT00000068122.2
      Conserved Domains (3) summary
      cd00063
      Location:149 → 250
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:316 → 617
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49 → 127
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      42354116..42668444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015139960.2 → XP_014995446.1  growth hormone receptor isoform X1

      UniProtKB/TrEMBL
      A0A1D5QFA6, A0A1D5RFI9, G7MV63
      Conserved Domains (3) summary
      cd00063
      Location:149 → 250
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:316 → 617
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49 → 127
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_028849121.1 → XP_028704954.1  growth hormone receptor isoform X2

      UniProtKB/TrEMBL
      G7MV63
      Conserved Domains (3) summary
      cd00063
      Location:147 → 248
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:314 → 615
      GHBP; Growth hormone receptor binding
      cl21522
      Location:47 → 125
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_015139959.2 → XP_014995445.1  growth hormone receptor isoform X1

      UniProtKB/TrEMBL
      A0A1D5QFA6, A0A1D5RFI9, G7MV63
      Conserved Domains (3) summary
      cd00063
      Location:149 → 250
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:316 → 617
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49 → 127
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79194.1 GenPept UniProtKB/Swiss-Prot:P79194

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials