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    LRP6 LDL receptor related protein 6 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695843, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LRP6provided by VGNC
    Official Full Name
    LDL receptor related protein 6provided by VGNC
    Primary source
    VGNC:VGNC:74446
    Locus tag
    EGK_03393
    See related
    Ensembl:ENSMMUG00000023317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See LRP6 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (13496433..13645349, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (12775989..12924967, complement)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114670790 Neighboring gene BCL2 like 14 Neighboring gene mortality factor 4-like protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene MANSC domain containing 1 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene AP-3 complex subunit sigma-1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Wnt receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway involved in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 6
    Names
    low-density lipoprotein receptor-related protein 6-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257719.1 → NP_001244648.1  low-density lipoprotein receptor-related protein 6 precursor

      See identical proteins and their annotated locations for NP_001244648.1

      Status: PROVISIONAL

      Source sequence(s)
      JU334495
      UniProtKB/TrEMBL
      A0A5F7ZGB8, A0A5K1UTM6, A0A8J8XIM2, F6Y514, G7N677
      Related
      ENSMMUP00000064636.1, ENSMMUT00000081160.1
      Conserved Domains (7) summary
      smart00135
      Location:483 → 524
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:1326 → 1360
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:55 → 93
      NHL; NHL repeat [structural motif]
      cl18310
      Location:55 → 272
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00058
      Location:150 → 190
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:592 → 627
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:1069 → 1110
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      13496433..13645349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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