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    TCP11 t-complex 11 [ Homo sapiens (human) ]

    Gene ID: 6954, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TCP11provided by HGNC
    Official Full Name
    t-complex 11provided by HGNC
    Primary source
    HGNC:HGNC:11658
    See related
    Ensembl:ENSG00000124678 MIM:186982; AllianceGenome:HGNC:11658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPPR; D6S230E
    Summary
    Involved in germ cell development. Located in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 154.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See TCP11 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35118075..35141339, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (34940885..34963547, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35085852..35109116, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:34855493-34856044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:34856778-34857660 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:34893897-34894070 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene NANOG hESC enhancer GRCh37_chr6:34960132-34960780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:34985455-34986058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24394 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35012271-35012922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35015552-35016400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35016401-35017247 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35025703-35026222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35027261-35027778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35036049-35036712 Neighboring gene NANOG hESC enhancer GRCh37_chr6:35037908-35038409 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35049025-35049696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35054004-35054504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35055243-35056070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35056071-35056896 Neighboring gene MPRA-validated peak5763 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24395 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:35115441-35116234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:35116235-35117028 Neighboring gene MPRA-validated peak5764 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:35152333-35152714 Neighboring gene Sharpr-MPRA regulatory region 4993 Neighboring gene uncharacterized LOC112267955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17084 Neighboring gene SCUBE3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17085 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:35211069-35212268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24396 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells. Wang F, et al. BMC Cancer, 2023 Sep 11. PMID 37697257, Free PMC Article
    2. Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide. Ma Y, et al. Mol Hum Reprod, 2002 Jan. PMID 11756566
    3. [Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene]. Ma YX, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2003 Apr. PMID 12905703
    4. [Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene]. Ma YX, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Feb. PMID 12545228
    5. Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex. Mazarakis ND, et al. Development, 1991 Feb. PMID 1893875

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells.
      Title: Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells.
    2. These results suggest that TCP11 may be responsible for sperm tail morphology and motility.
      Title: Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
    4. Results suggest that TCP11 gene is important in sperm function and fertility.
      Title: Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0229, MGC111103

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in germ cell development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein kinase A signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm midpiece ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 11 homolog
    Names
    fertilization-promoting peptide receptor
    t-complex 11 (a murine tcp homolog)
    t-complex 11 homolog
    t-complex 11, testis-specific
    testis secretory sperm-binding protein Li 222n

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261817.2 → NP_001248746.2  T-complex protein 11 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL138721
      Consensus CDS
      CCDS59018.2
      UniProtKB/TrEMBL
      A0A6E1WXZ9, B7ZAT8
      Related
      ENSP00000404479.3, ENST00000444780.7
      Conserved Domains (1) summary
      pfam05794
      Location:53 → 482
      Tcp11; T-complex protein 11

    2. NM_001261818.2 → NP_001248747.1  T-complex protein 11 homolog isoform 4

      See identical proteins and their annotated locations for NP_001248747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AF536533, AK301975, BF507838
      Consensus CDS
      CCDS59017.1
      UniProtKB/TrEMBL
      A0A140VK95
      Related
      ENSP00000363085.4, ENST00000373974.8
      Conserved Domains (1) summary
      pfam05794
      Location:29 → 451
      Tcp11; T-complex protein 11

    3. NM_001261819.2 → NP_001248748.1  T-complex protein 11 homolog isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AF260330, AK302022, DC396535
      Consensus CDS
      CCDS59016.1
      UniProtKB/TrEMBL
      B7ZAT8
      Related
      ENSP00000402816.2, ENST00000412155.6
      Conserved Domains (1) summary
      pfam05794
      Location:24 → 446
      Tcp11; T-complex protein 11

    4. NM_001261820.2 → NP_001248749.1  T-complex protein 11 homolog isoform 6

      See identical proteins and their annotated locations for NP_001248749.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, includes an alternate internal exon in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (6), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF536532, AF536533
      Consensus CDS
      CCDS59015.1
      UniProtKB/TrEMBL
      B7ZAT8
      Related
      ENSP00000478603.1, ENST00000611141.4
      Conserved Domains (1) summary
      pfam05794
      Location:1 → 424
      Tcp11; T-complex protein 11

    5. NM_001261821.2 → NP_001248750.1  T-complex protein 11 homolog isoform 6

      See identical proteins and their annotated locations for NP_001248750.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences, including the use of a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (6), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF536533, BC090050
      Consensus CDS
      CCDS59015.1
      UniProtKB/TrEMBL
      B7ZAT8
      Conserved Domains (1) summary
      pfam05794
      Location:1 → 424
      Tcp11; T-complex protein 11

    6. NM_001366323.2 → NP_001353252.1  T-complex protein 11 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL138721
      Consensus CDS
      CCDS59015.1
      UniProtKB/TrEMBL
      B7ZAT8
      Related
      ENSP00000415320.2, ENST00000418521.6
      Conserved Domains (1) summary
      pfam05794
      Location:1 → 424
      Tcp11; T-complex protein 11

    7. NM_001366324.2 → NP_001353253.1  T-complex protein 11 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL138721
      Consensus CDS
      CCDS4799.1
      UniProtKB/TrEMBL
      B7ZAT8
      Conserved Domains (1) summary
      pfam05794
      Location:15 → 425
      Tcp11; T-complex protein 11

    8. NM_001366325.2 → NP_001353254.1  T-complex protein 11 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL138721

    9. NM_001366326.2 → NP_001353255.1  T-complex protein 11 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL138721

    10. NM_001366327.2 → NP_001353256.1  T-complex protein 11 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL138721
      Conserved Domains (1) summary
      pfam05794
      Location:1 → 346
      Tcp11; T-complex protein 11

    11. NM_001366328.2 → NP_001353257.1  T-complex protein 11 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL138721
      Conserved Domains (1) summary
      pfam05794
      Location:1 → 346
      Tcp11; T-complex protein 11

    12. NM_001366329.2 → NP_001353258.1  T-complex protein 11 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL138721
      Conserved Domains (1) summary
      pfam05794
      Location:1 → 346
      Tcp11; T-complex protein 11

    13. NM_001366330.2 → NP_001353259.1  T-complex protein 11 homolog isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL138721

    14. NM_001366331.2 → NP_001353260.1  T-complex protein 11 homolog isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL138721

    15. NM_001366332.2 → NP_001353261.1  T-complex protein 11 homolog isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL138721
      UniProtKB/TrEMBL
      H0Y8T8
      Related
      ENSP00000422105.1, ENST00000502480.5

    16. NM_001370687.1 → NP_001357616.1  T-complex protein 11 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL138721
      Consensus CDS
      CCDS47413.2
      UniProtKB/Swiss-Prot
      B2RCE9, B3KQ27, B7Z7B5, B7Z7G1, B7Z7H4, B7Z7S8, E7EP29, J3KNG1, Q8NF85, Q8WWU5, Q9NQZ9, Q9NR39
      UniProtKB/TrEMBL
      A0A140VK95
      Related
      ENSP00000308708.6, ENST00000311875.11
      Conserved Domains (1) summary
      pfam05794
      Location:58 → 487
      Tcp11; T-complex protein 11

    17. NM_018679.6 → NP_061149.1  T-complex protein 11 homolog isoform 2

      See identical proteins and their annotated locations for NP_061149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, including the use of an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF536533
      Consensus CDS
      CCDS4799.1
      UniProtKB/TrEMBL
      B7ZAT8
      Related
      ENSP00000244645.3, ENST00000244645.7
      Conserved Domains (1) summary
      pfam05794
      Location:15 → 425
      Tcp11; T-complex protein 11

    RNA

    1. NR_158873.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL138721

    2. NR_158874.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL138721

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      35118075..35141339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514832.2 → XP_011513134.1  T-complex protein 11 homolog isoform X1

      See identical proteins and their annotated locations for XP_011513134.1

      Conserved Domains (1) summary
      pfam05794
      Location:1 → 346
      Tcp11; T-complex protein 11

    2. XM_047419278.1 → XP_047275234.1  T-complex protein 11 homolog isoform X1

    3. XM_011514830.3 → XP_011513132.2  T-complex protein 11 homolog isoform X2

      UniProtKB/TrEMBL
      B7Z7Q2
      Conserved Domains (1) summary
      pfam05794
      Location:71 → 439
      Tcp11; T-complex protein 11

    4. XM_047419277.1 → XP_047275233.1  T-complex protein 11 homolog isoform X5

      UniProtKB/TrEMBL
      B7ZAT8

    5. XM_047419276.1 → XP_047275232.1  T-complex protein 11 homolog isoform X4

      UniProtKB/TrEMBL
      B7ZAT8

    6. XM_047419275.1 → XP_047275231.1  T-complex protein 11 homolog isoform X3

      UniProtKB/TrEMBL
      A0A140VK95

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      34940885..34963547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356275.1 → XP_054212250.1  T-complex protein 11 homolog isoform X6

    2. XM_054356276.1 → XP_054212251.1  T-complex protein 11 homolog isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWU5.1 GenPept UniProtKB/Swiss-Prot:Q8WWU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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