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    BMP4 bone morphogenetic protein 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694618, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BMP4provided by VGNC
    Official Full Name
    bone morphogenetic protein 4provided by VGNC
    Primary source
    VGNC:VGNC:70263
    Locus tag
    EGK_18196
    See related
    Ensembl:ENSMMUG00000000429
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See BMP4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (116059900..116138327, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (115913663..116038792, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114679563 Neighboring gene uncharacterized LOC114679564 Neighboring gene ATP synthase subunit gamma, mitochondrial-like Neighboring gene uncharacterized LOC106999437 Neighboring gene cyclin dependent kinase inhibitor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables BMP receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bone morphogenetic protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      116059900..116138327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028851556.1 → XP_028707389.1  bone morphogenetic protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8J8Y0E3, F7ACJ7, G7MXX7
      Conserved Domains (2) summary
      cd19391
      Location:302 → 408
      TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
      pfam00688
      Location:41 → 275
      TGFb_propeptide; TGF-beta propeptide

    2. XM_001084801.3 → XP_001084801.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_001084801.1

      UniProtKB/TrEMBL
      A0A8J8Y0E3, F7ACJ7, G7MXX7
      Related
      ENSMMUP00000000577.2, ENSMMUT00000000626.4
      Conserved Domains (2) summary
      cd19391
      Location:302 → 408
      TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
      pfam00688
      Location:41 → 275
      TGFb_propeptide; TGF-beta propeptide

    3. XM_001084680.4 → XP_001084680.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_001084680.1

      UniProtKB/TrEMBL
      A0A8J8Y0E3, F7ACJ7, G7MXX7
      Conserved Domains (2) summary
      cd19391
      Location:302 → 408
      TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
      pfam00688
      Location:41 → 275
      TGFb_propeptide; TGF-beta propeptide

    4. XM_028851557.1 → XP_028707390.1  bone morphogenetic protein 4 isoform X2

      Conserved Domains (2) summary
      cd19391
      Location:349 → 455
      TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
      pfam00688
      Location:90 → 322
      TGFb_propeptide; TGF-beta propeptide

    5. XM_028851555.1 → XP_028707388.1  bone morphogenetic protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8J8Y0E3, F7ACJ7, G7MXX7
      Related
      ENSMMUP00000077296.1, ENSMMUT00000098019.1
      Conserved Domains (2) summary
      cd19391
      Location:302 → 408
      TGF_beta_BMP4_BMP2B; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins
      pfam00688
      Location:41 → 275
      TGFb_propeptide; TGF-beta propeptide
    Nucleotide Protein
    Heading Accession and Version

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