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    casd1 CAS1 domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 692268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    casd1provided by ZNC
    Official Full Name
    CAS1 domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-329
    See related
    Ensembl:ENSDARG00000023900 AllianceGenome:ZFIN:ZDB-GENE-060503-329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SOAT; Cas1p; zgc:136291; si:dkey-104m9.2
    Summary
    Predicted to enable N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. Orthologous to human CASD1 (CAS1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See casd1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (41006975..41035365)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (41419855..41447104)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488548 Neighboring gene collagen, type I, alpha 2 Neighboring gene sarcoglycan, epsilon Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene ankyrin repeat and SOCS box containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Sun J, et al. Development, 2018 Oct 2. PMID 30135188
    2. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylneuraminate (7)9-O-acetyltransferase; N-acetylneuraminate 9-O-acetyltransferase
    Names
    CAS1 domain-containing protein 1
    CAS1 protein
    sialate O-acetyltransferase
    NP_001265109.1
    XP_068071290.1
    XP_068071291.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278180.1 → NP_001265109.1  N-acetylneuraminate (7)9-O-acetyltransferase

      Status: VALIDATED

      Source sequence(s)
      BX640469
      UniProtKB/Swiss-Prot
      Q1JQ49, Q1LW89, Q4V8Z8
      UniProtKB/TrEMBL
      A0A0H2UKD6, A0A8M1P564
      Related
      ENSDARP00000049841.8, ENSDART00000049842.8
      Conserved Domains (2) summary
      pfam07779
      Location:293 → 766
      Cas1_AcylT; 10 TM Acyl Transferase domain found in Cas1p
      pfam13839
      Location:73 → 286
      PC-Esterase; GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      41006975..41035365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215190.1 → XP_068071291.1  N-acetylneuraminate 9-O-acetyltransferase isoform X2

      UniProtKB/Swiss-Prot
      Q1JQ49, Q1LW89, Q4V8Z8

    2. XM_068215189.1 → XP_068071290.1  N-acetylneuraminate 9-O-acetyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q1JQ49, Q1LW89, Q4V8Z8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045242.2: Suppressed sequence

      Description
      NM_001045242.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LW89.2 GenPept UniProtKB/Swiss-Prot:Q1LW89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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