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    Tbc1d22a TBC1 domain family, member 22a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689443, updated on 27-Dec-2024

    Summary

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    Symbol
    Tbc1d22aprovided by RGD
    Full Name
    TBC1 domain family, member 22aprovided by RGD
    Primary source
    RGD:1306588
    See related
    EnsemblRapid:ENSRNOG00000017057 AllianceGenome:RGD:1306588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306588
    Summary
    Predicted to enable 14-3-3 protein binding activity; GTPase activator activity; and protein homodimerization activity. Predicted to be active in Golgi apparatus. Orthologous to human TBC1D22A (TBC1 domain family member 22A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 49.9), Thymus (RPKM 49.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d22a in Genome Data Viewer
    Location:
    7q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (119172284..119457271)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (117292481..117577473)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (127081769..127227601)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 4 Neighboring gene uncharacterized LOC134479762 Neighboring gene ceramide kinase Neighboring gene TBC1 domain family, member 22a like Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC134479764 Neighboring gene uncharacterized LOC134479763 Neighboring gene uncharacterized LOC134479765

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. First crystallographic models of human TBC domains in the context of a family-wide structural analysis. Tempel W, et al. Proteins, 2008 Apr. PMID 18186464
    2. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. Greninger AL, et al. mBio, 2013 Apr 9. PMID 23572552, Free PMC Article
    3. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 22A
    Names
    TBC1 domain family member 22A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401878.2 → NP_001388807.1  TBC1 domain family member 22A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AH78
      Related
      ENSRNOP00000101010.1, ENSRNOT00000152968.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      119172284..119457271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080323.2 → XP_038936251.1  TBC1 domain family member 22A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPV1, A0A8I6AH78
      Related
      ENSRNOP00000080048.1, ENSRNOT00000094564.2
      Conserved Domains (1) summary
      pfam00566
      Location:276 → 466
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. XM_039080326.2 → XP_038936254.1  TBC1 domain family member 22A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AH78
      Conserved Domains (1) summary
      smart00164
      Location:216 → 442
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. XM_039080327.2 → XP_038936255.1  TBC1 domain family member 22A isoform X3

      Conserved Domains (1) summary
      pfam00566
      Location:50 → 240
      RabGAP-TBC; Rab-GTPase-TBC domain

    RNA

    1. XR_005487292.2 RNA Sequence

    2. XR_593675.4 RNA Sequence

      Related
      ENSRNOT00000022945.9
    Nucleotide Protein Strain
    Heading Accession and Version

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    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials