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    Adss1 adenylosuccinate synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adss1provided by RGD
    Official Full Name
    adenylosuccinate synthase 1provided by RGD
    Primary source
    RGD:1590342
    See related
    EnsemblRapid:ENSRNOG00000046763 AllianceGenome:RGD:1590342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AdSS 1; Adssl1
    Summary
    Enables several functions, including GTPase activity; actin filament binding activity; and adenylosuccinate synthase activity. Involved in several processes, including IMP metabolic process; cellular response to electrical stimulus; and proteinogenic amino acid metabolic process. Predicted to be active in cytoplasm. Biomarker of sarcoma. Orthologous to human ADSS1 (adenylosuccinate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2548.0) and Heart (RPKM 684.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adss1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137500549..137523087)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131679795..131702012)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137184818..137206694)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552388 Neighboring gene inverted formin 2 Neighboring gene SIVA1, apoptosis-inducing factor Neighboring gene AKT serine/threonine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification, crystallization, and properties of adenylosuccinate synthetase from rat skeletal muscle. Ogawa H, et al. J Biochem, 1977 Apr. PMID 18452
    2. Isotope exchange at equilibrium studies with rat muscle adenylosuccinate synthetase. Cooper BF, et al. Biochemistry, 1986 Nov 18. PMID 3542024
    3. Adenylosuccinate synthetase in rat liver: the existence of two types and their regulatory roles. Matsuda Y, et al. Biochem Biophys Res Commun, 1977 Sep 23. PMID 71897
    4. Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine. Xia Y, et al. J Biol Chem, 2003 Apr 11. PMID 12522136
    5. Isozyme shift of adenylosuccinate synthase in rat and human neoplasms. Ikegami T, et al. Adv Exp Med Biol, 1989. PMID 2560335

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylosuccinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylosuccinate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylosuccinate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' AMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aspartate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glutamine metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to muscle activity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylosuccinate synthase 1; adenylosuccinate synthetase isozyme 1
    Names
    AMPSase 1
    IMP--aspartate ligase 1
    adenylosuccinate synthase like 1
    adenylosuccinate synthetase, muscle isozyme

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432142.1 → NP_001419071.1  adenylosuccinate synthase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6G9X7, A6KBV5, M0R629

    2. NM_001432143.1 → NP_001419072.1  adenylosuccinate synthase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A7H6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137500549..137523087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113409.2 → XP_038969337.1  adenylosuccinate synthetase isozyme 1 isoform X2

      Conserved Domains (1) summary
      pfam00709
      Location:38 → 428
      Adenylsucc_synt; Adenylosuccinate synthetase

    2. XM_003750237.5 → XP_003750285.1  adenylosuccinate synthetase isozyme 1 isoform X1

      Related
      ENSRNOP00000064866.1, ENSRNOT00000073796.4
      Conserved Domains (1) summary
      pfam00709
      Location:35 → 454
      Adenylsucc_synt; Adenylosuccinate synthetase
    Nucleotide Protein Strain
    Heading Accession and Version

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