Phactr4 phosphatase and actin regulator 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phactr4provided by RGD
Official Full Name: phosphatase and actin regulator 4provided by RGD
Primary source: RGD:1592823
See related: EnsemblRapid:ENSRNOG00000046922 AllianceGenome:RGD:1592823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin binding activity; protein phosphatase 1 binding activity; and protein phosphatase activator activity. Predicted to be involved in several processes, including enteric nervous system development; morphogenesis of embryonic epithelium; and negative regulation of integrin-mediated signaling pathway. Predicted to be located in lamellipodium. Orthologous to human PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 93.6), Lung (RPKM 67.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (149828716..149904955, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (144549350..144621259, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (150533895..150609423, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Phactr4 to rescue chronic stress-induced depression-like behavior in rats via regulating neuroinflammation and neuroplasticity.
Title: Targeting Phactr4 to rescue chronic stress-induced depression-like behavior in rats via regulating neuroinflammation and neuroplasticity.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138093 (e-PCR)
- UniSTS:220180

BF403294 (e-PCR)
- UniSTS:246377

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase activator activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in closure of optic fissure	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatase and actin regulator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427181.1 → NP_001414110.1 phosphatase and actin regulator 4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

M0R7T1
NM_001427182.1 → NP_001414111.1 phosphatase and actin regulator 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AQY6, M0R7T1

Related

ENSRNOP00000100258.1, ENSRNOT00000153713.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

149828716..149904955 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288416.1 → XP_063144486.1 phosphatase and actin regulator 4 isoform X9

UniProtKB/TrEMBL

A0A8I6AQY6, M0R7T1
XM_063288413.1 → XP_063144483.1 phosphatase and actin regulator 4 isoform X6

UniProtKB/TrEMBL

M0R7T1
XM_039111275.2 → XP_038967203.1 phosphatase and actin regulator 4 isoform X2

UniProtKB/TrEMBL

M0R7T1

Conserved Domains (3) summary

smart00707
Location:620 → 644

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

PHA03247
Location:172 → 554

PHA03247; large tegument protein UL36; Provisional

pfam02755
Location:103 → 125

RPEL; RPEL repeat
XM_063288414.1 → XP_063144484.1 phosphatase and actin regulator 4 isoform X7

UniProtKB/TrEMBL

M0R7T1
XM_063288411.1 → XP_063144481.1 phosphatase and actin regulator 4 isoform X4

UniProtKB/TrEMBL

A0A8I6AJP4, M0R7T1

Related

ENSRNOP00000093257.1, ENSRNOT00000111943.2
XM_039111271.2 → XP_038967199.1 phosphatase and actin regulator 4 isoform X3

Related

ENSRNOP00000095468.2, ENSRNOT00000107632.2

Conserved Domains (2) summary

smart00707
Location:607 → 631

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

PHA03247
Location:159 → 541

PHA03247; large tegument protein UL36; Provisional
XM_039111276.2 → XP_038967204.1 phosphatase and actin regulator 4 isoform X1

Conserved Domains (3) summary

smart00707
Location:634 → 658

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

PHA03247
Location:186 → 568

PHA03247; large tegument protein UL36; Provisional

pfam02755
Location:117 → 139

RPEL; RPEL repeat
XM_039111273.2 → XP_038967201.1 phosphatase and actin regulator 4 isoform X5

UniProtKB/TrEMBL

A0A8I6AZ06, M0R7T1

Related

ENSRNOP00000094116.1, ENSRNOT00000105203.2

Conserved Domains (3) summary

smart00707
Location:592 → 616

RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

PHA03247
Location:144 → 526

PHA03247; large tegument protein UL36; Provisional

pfam02755
Location:75 → 97

RPEL; RPEL repeat
XM_063288415.1 → XP_063144485.1 phosphatase and actin regulator 4 isoform X8

UniProtKB/TrEMBL

M0R7T1