Pisd phosphatidylserine decarboxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pisdprovided by RGD
Official Full Name: phosphatidylserine decarboxylaseprovided by RGD
Primary source: RGD:1596729
See related: EnsemblRapid:ENSRNOG00000018319 AllianceGenome:RGD:1596729
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in several processes, including lipid droplet formation; mitochondrial protein catabolic process; and phosphatidylethanolamine biosynthetic process. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and lipid droplet. Predicted to be active in mitochondrion. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 62.3), Thymus (RPKM 56.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (82166401..82215479)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (77941927..77991021)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (83298630..83347697)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH133338 (e-PCR)
- UniSTS:216621

BE095985 (e-PCR)
- UniSTS:260653

Ptdss2 (e-PCR), detects polymorphism
- UniSTS:497494

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylserine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid droplet formation	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylserine decarboxylase proenzyme, mitochondrial

NP_001364036.1

EC 4.1.1.65

NP_001386579.1

EC 4.1.1.65

NP_001386580.1

EC 4.1.1.65

XP_017454997.1

EC 4.1.1.65

XP_038948369.1

EC 4.1.1.65

XP_063129690.1

EC 4.1.1.65

XP_063129691.1

EC 4.1.1.65

XP_063129692.1

EC 4.1.1.65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377107.2 → NP_001364036.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

D3ZAW2

UniProtKB/TrEMBL

A0A8I6GLT0, A6IK76

Related

ENSRNOP00000068695.3, ENSRNOT00000086090.3

Conserved Domains (1) summary

PLN02938
Location:81 → 407

PLN02938; phosphatidylserine decarboxylase
NM_001399650.1 → NP_001386579.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0G2JTF7

Related

ENSRNOP00000079457.2, ENSRNOT00000097659.2

Conserved Domains (1) summary

PLN02938
Location:70 → 373

PLN02938; phosphatidylserine decarboxylase
NM_001399651.1 → NP_001386580.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

82166401..82215479

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599508.3 → XP_017454997.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8L2QDB1

Related

ENSRNOP00000095790.2, ENSRNOT00000114187.2
XM_039092441.2 → XP_038948369.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0G2JTF7

Conserved Domains (1) summary

PLN02938
Location:70 → 373

PLN02938; phosphatidylserine decarboxylase
XM_063273621.1 → XP_063129691.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0G2JTF7
XM_063273622.1 → XP_063129692.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I5ZNJ4
XM_063273620.1 → XP_063129690.1 phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0G2JTF7