Alkal2 ALK and LTK ligand 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alkal2provided by RGD
Official Full Name: ALK and LTK ligand 2provided by RGD
Primary source: RGD:1587117
See related: EnsemblRapid:ENSRNOG00000005154 AllianceGenome:RGD:1587117
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam150b
Summary: Predicted to enable protein tyrosine kinase activator activity and signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron projection development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human ALKAL2 (ALK and LTK ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 13.0), Spleen (RPKM 12.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (53223204..53232794)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (47495645..47505235)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (49824725..49834921)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor signaling protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor signaling protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK5 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK5 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ALK and LTK ligand 2

Names: family with sequence similarity 150, member B; protein FAM150B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.