Zmynd19 zinc finger, MYND domain containing 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zmynd19provided by MGI
Official Full Name: zinc finger, MYND domain containing 19provided by MGI
Primary source: MGI:MGI:1914437
See related: Ensembl:ENSMUSG00000026974 AllianceGenome:MGI:1914437
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mizip; 2700064H14Rik
Summary: Predicted to enable metal ion binding activity. Located in cytoplasm; membrane; and synapse. Is expressed in central nervous system; male reproductive system; and urinary system. Orthologous to human ZMYND19 (zinc finger MYND-type containing 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 9.2), CNS E11.5 (RPKM 8.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.86 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24839789..24850882)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24949777..24960870)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data support the notion that MIZIP might interact with melanin-concentrating hormone receptor 1 (MCHR1) in a cell type specific manner in vivo, suggesting a role in the regulation of MCH signalling in distinct regions of the mammalian brain
Title: Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger MYND domain-containing protein 19

Names: MCH-R1-interacting zinc finger protein; melanin concentrating hormone receptor interacting zinc finger protein; melanin-concentrating hormone receptor 1-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026021.4 → NP_080297.1 zinc finger MYND domain-containing protein 19 isoform 1

See identical proteins and their annotated locations for NP_080297.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes encodes the longer isoform (1).

Source sequence(s)

AK012484, AL732585, AL935039, CJ154709

Consensus CDS

CCDS15742.1

UniProtKB/Swiss-Prot

Q8K1T3, Q9CQG3

Related

ENSMUSP00000028350.4, ENSMUST00000028350.9

Conserved Domains (2) summary

pfam01753
Location:174 → 212

zf-MYND; MYND finger

cl00083
Location:66 → 105

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
NM_147179.1 → NP_671708.1 zinc finger MYND domain-containing protein 19 isoform 2

See identical proteins and their annotated locations for NP_671708.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' most exon which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AL732525, AL732585, AL935039

Consensus CDS

CCDS79745.1

UniProtKB/Swiss-Prot

Q9CQG3

Related

ENSMUSP00000141788.2, ENSMUST00000148042.3

Conserved Domains (2) summary

pfam01753
Location:135 → 173

zf-MYND; MYND finger

cl00083
Location:27 → 66

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...