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    Fbxo25 F-box protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 66822, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxo25provided by MGI
    Official Full Name
    F-box protein 25provided by MGI
    Primary source
    MGI:MGI:1914072
    See related
    Ensembl:ENSMUSG00000038365 AllianceGenome:MGI:1914072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx25; 9130015I06Rik
    Summary
    Predicted to enable actin binding activity. Involved in protein ubiquitination. Located in nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system; liver; nervous system; sensory organ; and spleen. Orthologous to human FBXO25 (F-box protein 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 42.5), colon adult (RPKM 41.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo25 in Genome Data Viewer
    Location:
    8 A1.1; 8 6.42 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13957667..13992862)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13907736..13942875)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coordinator of PRMT5, differentiation stimulator Neighboring gene interferon induced transmembrane protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:13907572-13907873 Neighboring gene STARR-seq mESC enhancer starr_20776 Neighboring gene testis development related protein Neighboring gene STARR-seq mESC enhancer starr_20780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13992606-13992862 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13996330-13996563 Neighboring gene predicted gene 5907 Neighboring gene predicted gene, 53401

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors. Jang JW, et al. Biochem Biophys Res Commun, 2011 Jul 1. PMID 21596019
    2. FBXO25-associated nuclear domains: a novel subnuclear structure. Manfiolli AO, et al. Mol Biol Cell, 2008 May. PMID 18287534, Free PMC Article
    3. Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. Jeong HS, et al. Biochim Biophys Acta, 2015 Jun. PMID 25725482
    4. Characterization of FBX25, encoding a novel brain-expressed F-box protein. Hagens O, et al. Biochim Biophys Acta, 2006 Jan. PMID 16278047
    5. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Xue W, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22566646, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 transcriptional activity.
      Title: Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development.
    2. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development.
      Title: A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
    3. The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches.
      Title: FBXO25-associated nuclear domains: a novel subnuclear structure.
    4. mFbx25 shows predominantly neuronal expression and in adult mouse brain, expression is confined to the hippocampus, the cerebral cortex and the Purkinje cell layer
      Title: Characterization of FBX25, encoding a novel brain-expressed F-box protein.
    5. FBXO25 is a novel F-box protein analogous to atrogin-1, which is not involved in muscle atrophy.
      Title: FBXO25, an F-box protein homologue of atrogin-1, is not induced in atrophying muscle.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347316.1 → NP_001334245.1  F-box only protein 25 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses and alternate in-frame splice site, compared to variant 3. The encoded isoform (1) is shorter than isoform 3.
      Source sequence(s)
      AC139186, AK134722, CJ147979
      Consensus CDS
      CCDS85507.1
      UniProtKB/TrEMBL
      A0A1B0GRC8, Q3UYF5
      Related
      ENSMUSP00000147467.2, ENSMUST00000209913.2

    2. NM_001359061.1 → NP_001345990.1  F-box only protein 25 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3)
      Source sequence(s)
      AC139186
      UniProtKB/TrEMBL
      Q3UYF5

    3. NM_025785.3 → NP_080061.1  F-box only protein 25 isoform 2

      See identical proteins and their annotated locations for NP_080061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 3. The encoded isoform (2) is shorter than isoform 3.
      Source sequence(s)
      AC139186
      Consensus CDS
      CCDS22118.1
      UniProtKB/Swiss-Prot
      Q9D2Y6, Q9D8H3
      UniProtKB/TrEMBL
      Q3UYF5
      Related
      ENSMUSP00000039544.4, ENSMUST00000043520.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13957667..13992862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243729.2 → XP_030099589.1  F-box only protein 25 isoform X1

      UniProtKB/TrEMBL
      Q3UYF5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2Y6.1 GenPept UniProtKB/Swiss-Prot:Q9D2Y6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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