Hmcn2 hemicentin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmcn2provided by MGI
Official Full Name: hemicentin 2provided by MGI
Primary source: MGI:MGI:2677838
See related: Ensembl:ENSMUSG00000055632 AllianceGenome:MGI:2677838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D030068H01
Summary: Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Located in several cellular components, including basement membrane; cell cortex; and extracellular region. Is expressed in several structures, including early embryo; gut; hindlimb muscle; lung; and skin. Orthologous to human HMCN2 (hemicentin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 30.0), duodenum adult (RPKM 18.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.81 cM

Exon count:: 99

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (31204273..31350751)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (31314255..31460738)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

02.MMHAP9FRA8.seq (e-PCR)
- UniSTS:122720

D2Mit296 (e-PCR), detects polymorphism
- UniSTS:129186

D2Mit64 (e-PCR), detects polymorphism
- UniSTS:129459

D2Mit152 (e-PCR), detects polymorphism
- UniSTS:129013

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables axon guidance receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hemicentin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370902.1 → NP_001357831.1 hemicentin-2 precursor

Status: VALIDATED

Source sequence(s)

AL732564, AL732572, AL928861

UniProtKB/Swiss-Prot

A2AJ76, Q8BNH3

Related

ENSMUSP00000109160.3, ENSMUST00000113532.9

Conserved Domains (12) summary

smart00408
Location:4242 → 4304

IGc2; Immunoglobulin C-2 Type

smart00179
Location:4879 → 4918

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:793 → 876

IG; Immunoglobulin

smart00410
Location:707 → 783

IG_like; Immunoglobulin like

cd00198
Location:38 → 196

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam07645
Location:4684 → 4727

EGF_CA; Calcium-binding EGF domain

cd00096
Location:3239 → 3303

Ig; Immunoglobulin domain

pfam07474
Location:4406 → 4588

G2F; G2F domain

pfam07679
Location:4318 → 4404

I-set; Immunoglobulin I-set domain

pfam13927
Location:1981 → 2056

Ig_3; Immunoglobulin domain

pfam14670
Location:4647 → 4682

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl11960
Location:1262 → 1336

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

31204273..31350751

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498503.5 → XP_006498566.1 hemicentin-2 isoform X2

UniProtKB/Swiss-Prot

A2AJ76, Q8BNH3

Conserved Domains (12) summary

smart00408
Location:4259 → 4321

IGc2; Immunoglobulin C-2 Type

smart00179
Location:4789 → 4829

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:1553 → 1633

IG; Immunoglobulin

smart00410
Location:793 → 876

IG_like; Immunoglobulin like

cd00198
Location:38 → 196

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam07645
Location:4701 → 4744

EGF_CA; Calcium-binding EGF domain

cd00096
Location:3256 → 3320

Ig; Immunoglobulin domain

pfam07474
Location:4423 → 4605

G2F; G2F domain

pfam07679
Location:4335 → 4421

I-set; Immunoglobulin I-set domain

pfam13927
Location:1998 → 2073

Ig_3; Immunoglobulin domain

pfam14670
Location:4664 → 4699

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl11960
Location:1262 → 1336

Ig; Immunoglobulin domain
XM_006498501.5 → XP_006498564.1 hemicentin-2 isoform X1

UniProtKB/Swiss-Prot

A2AJ76, Q8BNH3

Conserved Domains (12) summary

smart00408
Location:4259 → 4321

IGc2; Immunoglobulin C-2 Type

smart00179
Location:4896 → 4935

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:707 → 783

IG; Immunoglobulin

smart00410
Location:793 → 876

IG_like; Immunoglobulin like

cd00198
Location:38 → 196

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam07645
Location:4701 → 4744

EGF_CA; Calcium-binding EGF domain

cd00096
Location:3256 → 3320

Ig; Immunoglobulin domain

pfam07474
Location:4423 → 4605

G2F; G2F domain

pfam07679
Location:4335 → 4421

I-set; Immunoglobulin I-set domain

pfam13927
Location:1998 → 2073

Ig_3; Immunoglobulin domain

pfam14670
Location:4664 → 4699

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl11960
Location:1262 → 1336

Ig; Immunoglobulin domain
XM_006498504.2 → XP_006498567.1 hemicentin-2 isoform X3

UniProtKB/Swiss-Prot

A2AJ76, Q8BNH3

Conserved Domains (11) summary

smart00408
Location:4104 → 4166

IGc2; Immunoglobulin C-2 Type

smart00179
Location:4741 → 4780

EGF_CA; Calcium-binding EGF-like domain

smart00409
Location:638 → 721

IG; Immunoglobulin

smart00410
Location:552 → 628

IG_like; Immunoglobulin like

pfam07645
Location:4546 → 4589

EGF_CA; Calcium-binding EGF domain

cd00096
Location:3101 → 3165

Ig; Immunoglobulin domain

pfam07474
Location:4268 → 4450

G2F; G2F domain

pfam07679
Location:4180 → 4266

I-set; Immunoglobulin I-set domain

pfam13927
Location:1843 → 1918

Ig_3; Immunoglobulin domain

pfam14670
Location:4509 → 4544

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl11960
Location:1107 → 1181

Ig; Immunoglobulin domain

RNA

XR_003953689.2 RNA Sequence

Related

ENSMUST00000226996.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177649.5: Suppressed sequence

Description

NM_177649.5: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.