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    Dda1 DET1 and DDB1 associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 66498, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dda1provided by MGI
    Official Full Name
    DET1 and DDB1 associated 1provided by MGI
    Primary source
    MGI:MGI:1913748
    See related
    Ensembl:ENSMUSG00000074247 AllianceGenome:MGI:1913748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500034J01Rik; 1700095J19Rik
    Summary
    Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in cerebral cortex. Orthologous to human DDA1 (DET1 and DDB1 associated 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 57.3), adrenal adult (RPKM 55.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dda1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71921816..71928743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71469172..71476099)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6651 Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene anoctamin 8 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene GTP binding protein 3 Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle. Cheng L, et al. J Cell Mol Med, 2017 Aug. PMID 28211159, Free PMC Article
    2. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DET1- and DDB1-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294258.1 → NP_001281187.1  DET1- and DDB1-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA036394, AC127416, AK032966, BY316490
      Consensus CDS
      CCDS80894.1
      UniProtKB/TrEMBL
      D3YXY5
      Related
      ENSMUSP00000123665.2, ENSMUST00000147642.2
      Conserved Domains (1) summary
      pfam10172
      Location:3 → 46
      DDA1; Det1 complexing ubiquitin ligase

    2. NM_001294259.1 → NP_001281188.1  DET1- and DDB1-associated protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC127416, AK032966, BY297077, BY316490
      UniProtKB/Swiss-Prot
      Q9D9Z5
      Conserved Domains (1) summary
      pfam10172
      Location:2 → 38
      DDA1; Det1 complexing ubiquitin ligase

    3. NM_025600.2 → NP_079876.1  DET1- and DDB1-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_079876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC127416, AK032966, BB610194, BY316490
      Consensus CDS
      CCDS52584.1
      UniProtKB/Swiss-Prot
      Q3UDQ1, Q9D9Z5
      Related
      ENSMUSP00000121042.2, ENSMUST00000124745.8
      Conserved Domains (1) summary
      pfam10172
      Location:3 → 65
      DDA1; Det1 complexing ubiquitin ligase

    RNA

    1. NR_122114.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC127416, AK032966, AK149117, BY316490
      Related
      ENSMUST00000130098.8

    2. NR_122115.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC127416, AK032966, AK149980, BY316490
      Related
      ENSMUST00000135052.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71921816..71928743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242317.2 → XP_011240619.1  DET1- and DDB1-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10172
      Location:47 → 90
      DDA1; Det1 complexing ubiquitin ligase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9Z5.1 GenPept UniProtKB/Swiss-Prot:Q9D9Z5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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