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    Dpy30 dpy-30, histone methyltransferase complex regulatory subunit [ Mus musculus (house mouse) ]

    Gene ID: 66310, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dpy30provided by MGI
    Official Full Name
    dpy-30, histone methyltransferase complex regulatory subunitprovided by MGI
    Primary source
    MGI:MGI:1913560
    See related
    Ensembl:ENSMUSG00000024067 AllianceGenome:MGI:1913560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810410M20Rik
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in endosomal transport and transcription initiation-coupled chromatin remodeling. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in several structures, including alimentary system; cerebral cortex; lung; nose; and submandibular gland primordium. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 36.7), testis adult (RPKM 34.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpy30 in Genome Data Viewer
    Location:
    17 E2; 17 45.64 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (74606469..74630939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (74299474..74323944, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mediator of cell motility 1 Neighboring gene F-box protein 34 pseudogene Neighboring gene predicted gene, 52299 Neighboring gene STARR-seq mESC enhancer starr_43214 Neighboring gene STARR-seq mESC enhancer starr_43216 Neighboring gene STARR-positive B cell enhancer ABC_E9964 Neighboring gene predicted gene, 31328 Neighboring gene predicted gene 9349

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of chromatin modulator Dpy30 in osteoclast differentiation and function. Zhao Y, et al. Bone, 2022 Jun. PMID 35307321, Free PMC Article
    2. Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells. Yang Z, et al. J Exp Med, 2016 Oct 17. PMID 27647347, Free PMC Article
    3. Hijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer. Yang Z, et al. J Clin Invest, 2018 Aug 1. PMID 29870403, Free PMC Article
    4. DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications. Liu B. Biochem Biophys Res Commun, 2018 Dec 9. PMID 30448059
    5. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Jiang H, et al. Cell, 2011 Feb 18. PMID 21335234, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30.
      Title: The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30.
    2. Role of chromatin modulator Dpy30 in osteoclast differentiation and function.
      Title: Role of chromatin modulator Dpy30 in osteoclast differentiation and function.
    3. A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.
      Title: A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.
    4. These results reveal a critical role of DPY30 in glucose homeostasis.
      Title: DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications.
    5. Dpy30-deficient hematopoietic stem and progenitor cells cannot differentiate or efficiently up-regulate lineage-regulatory genes, and eventually fail to sustain for long term.
      Title: Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells.
    6. Dpy30 role in cellular reprogramming and its interactions with Set1 complex
      Title: Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.
    7. Results indicate an essential functional role for Dpy-30 and SET1/MLL complex-mediated H3K4 methylation, as a component of the bivalent mark, at developmental genes during the embryonic stem cells fate transitions.
      Title: Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Set1C/COMPASS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of histone methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein dpy-30 homolog
    Names
    dosage compensation-related protein DPY30
    dpy-30 homolog
    dpy-30-like protein
    dpy-30L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146222.1 → NP_001139694.1  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_001139694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK013073, BX518196
      Consensus CDS
      CCDS28970.1
      UniProtKB/Swiss-Prot
      Q99LT0
      UniProtKB/TrEMBL
      Q7TQ15
      Related
      ENSMUSP00000108190.4, ENSMUST00000112571.5
      Conserved Domains (1) summary
      pfam05186
      Location:52 → 93
      Dpy-30; Dpy-30 motif

    2. NM_001146223.1 → NP_001139695.1  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_001139695.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK013073, AK077902, AV460563
      Consensus CDS
      CCDS28970.1
      UniProtKB/Swiss-Prot
      Q99LT0
      UniProtKB/TrEMBL
      Q7TQ15
      Related
      ENSMUSP00000156795.2, ENSMUST00000233581.2
      Conserved Domains (1) summary
      pfam05186
      Location:52 → 93
      Dpy-30; Dpy-30 motif

    3. NM_001146224.1 → NP_001139696.1  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_001139696.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK003688, AK013073, BY123406
      Consensus CDS
      CCDS28970.1
      UniProtKB/Swiss-Prot
      Q99LT0
      UniProtKB/TrEMBL
      Q7TQ15
      Related
      ENSMUSP00000156830.2, ENSMUST00000232687.2
      Conserved Domains (1) summary
      pfam05186
      Location:52 → 93
      Dpy-30; Dpy-30 motif

    4. NM_024428.4 → NP_077746.3  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_077746.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK013073, BU961422
      Consensus CDS
      CCDS28970.1
      UniProtKB/Swiss-Prot
      Q99LT0
      UniProtKB/TrEMBL
      Q7TQ15
      Related
      ENSMUSP00000126702.2, ENSMUST00000164832.9
      Conserved Domains (1) summary
      pfam05186
      Location:52 → 93
      Dpy-30; Dpy-30 motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      74606469..74630939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LT0.1 GenPept UniProtKB/Swiss-Prot:Q99LT0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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