SUMO3 small ubiquitin like modifier 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SUMO3provided by HGNC
Official Full Name: small ubiquitin like modifier 3provided by HGNC
Primary source: HGNC:HGNC:11124
See related: Ensembl:ENSG00000184900 MIM:602231; AllianceGenome:HGNC:11124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SMT3A; Smt3B; SMT3H1; SUMO-3
Summary: This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
Expression: Ubiquitous expression in brain (RPKM 42.6), bone marrow (RPKM 40.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q22.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (44805617..44818062, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (43165885..43178512, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (46225532..46237977, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55.
Title: SUMO-3 promotes the ubiquitin-dependent turnover of TRIM55.
SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80-K307.
Title: SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80-K307.
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Title: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
SUMO paralogue-specific functions revealed through systematic analysis of human knockout cell lines and gene expression data.
Title: SUMO paralogue-specific functions revealed through systematic analysis of human knockout cell lines and gene expression data.
Opposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer.
Title: Opposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer.
Small ubiquitin-related modifier (SUMO) 3 and SUMO4 gene polymorphisms in Parkinson's disease.
Title: Small ubiquitin-related modifier (SUMO) 3 and SUMO4 gene polymorphisms in Parkinson's disease.
RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
Title: RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
The SUMO3 modification of PIAS1 modulates AR cellular distribution and stability.
Title: SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability.
Formation of SUMO3-conjugated chains of MAVS induced by poly(dA:dT), a ligand of RIG-I, enhances the aggregation of MAVS that drives the secretion of interferon-beta in human keratinocytes.
Title: Formation of SUMO3-conjugated chains of MAVS induced by poly(dA:dT), a ligand of RIG-I, enhances the aggregation of MAVS that drives the secretion of interferon-β in human keratinocytes.
Study demonstrated for the first time that PKA stimulated OAT3 expression and transport activity by altering the trafficking kinetics of OAT3 possibly through the crosstalk between SUMOylation and ubiquitination. OAT3 is subjected to post-translational modification by SUMO-2 and SUMO-3 not by SUMO-1.
Title: Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Expression of HIV-1 Tat downregulates the abundance of SMT3 suppressor of mif two 3 homolog 3 (SUMO3) in the nucleoli of Jurkat T-cells	PubMed
integrase	gag-pol	SUMOylation of HIV-1 IN at positions K46, K136, and K244 by SUMO involves HIV-1 infectivity	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-87715 (e-PCR)
- UniSTS:59217

D12S2014 (e-PCR)
- UniSTS:51561

RH26902 (e-PCR)
- UniSTS:84111

D21S1937 (e-PCR)
- UniSTS:7348

D21S1722E (e-PCR)
- UniSTS:150778

D1S1929E (e-PCR)
- UniSTS:151290

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in kinetochore	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ubiquitin-related modifier 3

Names: SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 3; ubiquitin-like protein SMT3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033969.1 RefSeqGene

Range

5068..17513

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001286416.2 → NP_001273345.1 small ubiquitin-related modifier 3 isoform 2

See identical proteins and their annotated locations for NP_001273345.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site compared to variant 1. The resulting longer isoform (2) has an internal protein segment not found in isoform 1.

Source sequence(s)

AK300822, BC000036

Consensus CDS

CCDS68220.1

UniProtKB/Swiss-Prot

P55854

Related

ENSP00000409666.2, ENST00000411651.6

Conserved Domains (2) summary

cd01763
Location:7 → 130

Sumo; Small ubiquitin-related modifier (SUMO)

smart00213
Location:17 → 123

UBQ; Ubiquitin homologues
NM_006936.3 → NP_008867.2 small ubiquitin-related modifier 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_008867.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter isoform (1).

Source sequence(s)

BC000036, BC008420

Consensus CDS

CCDS33587.1

UniProtKB/Swiss-Prot

B2R5X4, B4DUW4, P55854, Q53HI9, Q6FGD4, Q9BWR4

Related

ENSP00000330343.7, ENST00000332859.11

Conserved Domains (1) summary

cd16115
Location:16 → 87

Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins