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    Vps33a VPS33A core subunit of CORVET and HOPS complexes [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65081, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vps33aprovided by RGD
    Official Full Name
    VPS33A core subunit of CORVET and HOPS complexesprovided by RGD
    Primary source
    RGD:620643
    See related
    EnsemblRapid:ENSRNOG00000056889 AllianceGenome:RGD:620643
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    r-Vps33a
    Summary
    Predicted to be involved in several processes, including autophagosome maturation; melanosome localization; and regulation of lysosomal lumen pH. Predicted to act upstream of or within pigmentation; platelet formation; and regulation of developmental pigmentation. Predicted to be located in autophagosome; endosome; and perinuclear region of cytoplasm. Predicted to be part of several cellular components, including AP-3 adaptor complex; CORVET complex; and clathrin complex. Predicted to be active in lysosome. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 79.2), Brain (RPKM 78.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vps33a in Genome Data Viewer
    Location:
    12q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38685484..38710668)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33024596..33051399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38459816..38482903)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 1 Neighboring gene uncharacterized LOC134481295 Neighboring gene uncharacterized LOC120095846 Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene leucine rich repeat containing 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation. Suzuki T, et al. Proc Natl Acad Sci U S A, 2003 Feb 4. PMID 12538872, Free PMC Article
    2. Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms. Kondo H, et al. Hum Mol Genet, 2017 Jan 1. PMID 28013294
    3. Genetic control of glucuronidase induction in mice. Swank RT, et al. J Mol Biol, 1973 Dec 5. PMID 4777306
    4. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Gissen P, et al. Hum Mol Genet, 2005 May 15. PMID 15790593
    5. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. Kim BY, et al. J Biol Chem, 2001 Aug 3. PMID 11382755

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endosome to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanosome localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in melanosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within platelet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lysosomal lumen pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lysosomal lumen pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lysosomal lumen pH ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-3 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CORVET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CORVET complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CORVET complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HOPS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of clathrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 33A
    Names
    VPS33A CORVET/HOPS core subunit
    vacuolar protein sorting 33 homolog A
    vacuolar protein sorting 33A
    vacuolar protein sorting protein 33a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022961.3 → NP_075250.2  vacuolar protein sorting-associated protein 33A

      See identical proteins and their annotated locations for NP_075250.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105752
      UniProtKB/Swiss-Prot
      Q63615
      UniProtKB/TrEMBL
      A0A0G2K5N1, A0A9K3Y802, Q3KRF0
      Related
      ENSRNOP00000073489.2, ENSRNOT00000090343.3
      Conserved Domains (1) summary
      pfam00995
      Location:34 → 585
      Sec1; Sec1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38685484..38710668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089725.2 → XP_038945653.1  vacuolar protein sorting-associated protein 33A isoform X1

      Conserved Domains (1) summary
      pfam00995
      Location:34 → 435
      Sec1; Sec1 family

    2. XM_039089726.2 → XP_038945654.1  vacuolar protein sorting-associated protein 33A isoform X2

      Conserved Domains (1) summary
      pfam00995
      Location:34 → 317
      Sec1; Sec1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63615.1 GenPept UniProtKB/Swiss-Prot:Q63615

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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