Ireb2 iron responsive element binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ireb2provided by RGD
Official Full Name: iron responsive element binding protein 2provided by RGD
Primary source: RGD:621539
See related: EnsemblRapid:ENSRNOG00000013271 AllianceGenome:RGD:621539
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Irp2
Summary: Enables 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to iron(III) ion; and response to hypoxia. Located in axon and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 216.0), Adrenal (RPKM 177.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (64124152..64207702)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (55228080..55311613)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (59450974..59503634)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2.
Title: miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2.
These results suggest that the genetic ablation of iPLA2b increased iron uptake in the brain through the activation of IRP2 and upregulation of DMT1, which may be associated with mitochondrial dysfunction.
Title: Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1.
Vitamin A is involved in the regulation of IRP2, subsequently affecting iron metabolism gene expressions, such as Ferritin and transferrin receptor.
Title: Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2.
IRP-2 serves as an important regulator of iron metabolism, and regulates iron uptake from the intestine by controlling the expression of ferritin mRNA at the post transcriptional level.
Title: [Expression of iron regulatory protein-2 and ferritins in intestinal mucosa of rats with iron deficiency].
reversible phosphorylation of IRP2 during G(2)/M has a role in modulating the iron-independent expression of ferritin and other IRE-containing mRNAs during the cell cycle.
Title: Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048385 (e-PCR)
- UniSTS:109587

IREB2 (e-PCR)
- UniSTS:503115

RH144331 (e-PCR)
- UniSTS:233576

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-responsive element binding	IDA Inferred from Direct Assay more info	PubMed
enables iron-responsive element binding	IEA Inferred from Electronic Annotation more info
enables iron-responsive element binding	ISO Inferred from Sequence Orthology more info
enables mRNA regulatory element binding translation repressor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables regulatory region RNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to iron(III) ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to iron(III) ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to manganese ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mercaptoethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in citrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organismal-level iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypobaric hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron(II) ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron(III) ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to kainic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle atrophy	IEP Inferred from Expression Pattern more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: iron-responsive element-binding protein 2

Names: IRE-BP 2; iron regulatory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022863.2 → NP_074054.2 iron-responsive element-binding protein 2

See identical proteins and their annotated locations for NP_074054.2

Status: PROVISIONAL

Source sequence(s)

BC081798

UniProtKB/Swiss-Prot

Q62751, Q66HL4

UniProtKB/TrEMBL

A0A8I5ZQ27, A6J4M8

Related

ENSRNOP00000017900.4, ENSRNOT00000017900.6

Conserved Domains (1) summary

PTZ00092
Location:3 → 961

PTZ00092; aconitate hydratase-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

64124152..64207702

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082090.2 → XP_038938018.1 iron-responsive element-binding protein 2 isoform X3

UniProtKB/TrEMBL

A0A0G2JXC9, A0A8I5ZQ27

Conserved Domains (1) summary

PTZ00092
Location:6 → 962

PTZ00092; aconitate hydratase-like protein; Provisional
XM_063266079.1 → XP_063122149.1 iron-responsive element-binding protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZQ27
XM_063266078.1 → XP_063122148.1 iron-responsive element-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZQ27
XM_063266080.1 → XP_063122150.1 iron-responsive element-binding protein 2 isoform X4

UniProtKB/TrEMBL

A0A8I5ZQ27

Related

ENSRNOP00000070223.2, ENSRNOT00000077922.3