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    GPR135 G protein-coupled receptor 135 [ Homo sapiens (human) ]

    Gene ID: 64582, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR135provided by HGNC
    Official Full Name
    G protein-coupled receptor 135provided by HGNC
    Primary source
    HGNC:HGNC:19991
    See related
    Ensembl:ENSG00000181619 MIM:607970; AllianceGenome:HGNC:19991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUMNPIIY20
    Summary
    Enables arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 3.7), ovary (RPKM 1.1) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR135 in Genome Data Viewer
    Location:
    14q23.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (59452783..59465380, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (53659699..53672299, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59927477..59932098, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5803 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59655908-59656667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8458 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34577 Neighboring gene peptidylprolyl isomerase A pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 14842 Neighboring gene dishevelled associated activator of morphogenesis 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5805 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59797736-59798544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8459 Neighboring gene NANOG hESC enhancer GRCh37_chr14:59862330-59862839 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8461 Neighboring gene uncharacterized LOC124903326 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene JNK1/MAPK8 associated membrane protein Neighboring gene coiled-coil domain containing 175

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Asbestos-associated genome-wide DNA methylation changes in lung cancer. Kettunen E, et al. Int J Cancer, 2017 Nov 15. PMID 28722770
    2. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions. Oishi A, et al. Sci Rep, 2017 Aug 21. PMID 28827538, Free PMC Article
    3. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
    4. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. Lin CW, et al. J Drug Target, 2012 Jul. PMID 22632162
    5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, these data show that GPR61, GPR62 and GPR135 are unable to bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors.
      Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions.
    2. GPR135 hypermethylation is associated with lung cancer.
      Title: Asbestos-associated genome-wide DNA methylation changes in lung cancer.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of G protein-coupled receptor 135 (GPR135) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arrestin family protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 135
    Names
    probable G-protein coupled receptor 135

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022571.6 → NP_072093.2  G-protein coupled receptor 135

      See identical proteins and their annotated locations for NP_072093.2

      Status: VALIDATED

      Source sequence(s)
      AL159140, AY288418, BC032831, BX094623
      Consensus CDS
      CCDS9738.1
      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Related
      ENSP00000378548.1, ENST00000395116.2
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      59452783..59465380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021599.3 → XP_016877088.1  G-protein coupled receptor 135 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_017021598.3 → XP_016877087.1  G-protein coupled receptor 135 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_024449696.2 → XP_024305464.1  G-protein coupled receptor 135 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_024449695.2 → XP_024305463.1  G-protein coupled receptor 135 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_024449694.2 → XP_024305462.1  G-protein coupled receptor 135 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Related
      ENSP00000432696.1, ENST00000481661.1
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_024449693.2 → XP_024305461.1  G-protein coupled receptor 135 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_017021596.3 → XP_016877085.1  G-protein coupled receptor 135 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z604, Q86SM3, Q8IZ08, Q8NH39
      Conserved Domains (2) summary
      cd14964
      Location:139 → 161
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:120 → 398
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      53659699..53672299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376614.1 → XP_054232589.1  G-protein coupled receptor 135 isoform X1

    2. XM_054376612.1 → XP_054232587.1  G-protein coupled receptor 135 isoform X1

    3. XM_054376613.1 → XP_054232588.1  G-protein coupled receptor 135 isoform X1

    4. XM_054376611.1 → XP_054232586.1  G-protein coupled receptor 135 isoform X1

    5. XM_054376609.1 → XP_054232584.1  G-protein coupled receptor 135 isoform X1

    6. XM_054376608.1 → XP_054232583.1  G-protein coupled receptor 135 isoform X1

    7. XM_054376610.1 → XP_054232585.1  G-protein coupled receptor 135 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZ08.2 GenPept UniProtKB/Swiss-Prot:Q8IZ08

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