Bard1 BRCA1 associated RING domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bard1provided by RGD
Official Full Name: BRCA1 associated RING domain 1provided by RGD
Primary source: RGD:621072
See related: EnsemblRapid:ENSRNOG00000014960 AllianceGenome:RGD:621072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to testosterone stimulus; and response to aldosterone. Predicted to be located in cytoplasmic ribonucleoprotein granule and nuclear speck. Predicted to be part of nucleus. Biomarker of retinal degeneration. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 105.6), Spleen (RPKM 70.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (80069960..80144167, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (72616070..72694553, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (78297723..78368777, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Assignment of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping
Title: Assignment of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping.
Full-length BARD1 might be involved in apoptotic control in spermatogonia and primary spermatocytes. Switch to BRCA1-independent BARD1beta might be necessary to induce apoptosis in BRCA1-expressing meiotic spermatocytes and early round spermatids.
Title: BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cellular response to follicle-stimulating hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K6-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K6-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K6-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	HEP more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-A complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-A complex	ISO Inferred from Sequence Orthology more info
part_of BRCA1-B complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-B complex	ISO Inferred from Sequence Orthology more info
part_of BRCA1-BARD1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-BARD1 complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-BARD1 complex	ISO Inferred from Sequence Orthology more info
part_of BRCA1-BARD1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of BRCA1-C complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-C complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
part_of nuclear ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: BRCA1-associated RING domain protein 1

Names: RING-type E3 ubiquitin transferase BARD1

NP_072144.2

EC 2.3.2.27

XP_038940101.1

EC 2.3.2.27

XP_038940102.1

EC 2.3.2.27

XP_038940103.1

EC 2.3.2.27

XP_038940104.1

EC 2.3.2.27

XP_063123758.1

EC 2.3.2.27

XP_063123759.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022622.2 → NP_072144.2 BRCA1-associated RING domain protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9QZH2

UniProtKB/TrEMBL

A0A0G2K9Y6, A6KFF8

Related

ENSRNOP00000075183.1, ENSRNOT00000087870.3

Conserved Domains (6) summary

COG0666
Location:366 → 558

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:417 → 448

ANK; ANK repeat [structural motif]

cd17720
Location:662 → 762

BRCT_Bard1_rpt2; second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

cd17734
Location:561 → 637

BRCT_Bard1_rpt1; first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

pfam12796
Location:422 → 514

Ank_2; Ankyrin repeats (3 copies)

pfam14835
Location:35 → 99

zf-RING_6; zf-RING of BARD1-type protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

80069960..80144167 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084176.2 → XP_038940104.1 BRCA1-associated RING domain protein 1 isoform X5

UniProtKB/TrEMBL

G3V7X7, Q6J724

Related

ENSRNOP00000020414.4, ENSRNOT00000020414.6

Conserved Domains (4) summary

sd00045
Location:279 → 316

ANK; ANK repeat [structural motif]

cd17720
Location:497 → 597

BRCT_Bard1_rpt2; second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

cd17734
Location:396 → 472

BRCT_Bard1_rpt1; first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

pfam12796
Location:262 → 349

Ank_2; Ankyrin repeats (3 copies)
XM_039084175.2 → XP_038940103.1 BRCA1-associated RING domain protein 1 isoform X4

UniProtKB/TrEMBL

Q6J724

Conserved Domains (5) summary

COG0666
Location:228 → 420

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:279 → 310

ANK; ANK repeat [structural motif]

cd17720
Location:524 → 624

BRCT_Bard1_rpt2; second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

cd17734
Location:423 → 499

BRCT_Bard1_rpt1; first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

pfam12796
Location:284 → 376

Ank_2; Ankyrin repeats (3 copies)
XM_063267688.1 → XP_063123758.1 BRCA1-associated RING domain protein 1 isoform X3
XM_039084174.2 → XP_038940102.1 BRCA1-associated RING domain protein 1 isoform X2

UniProtKB/Swiss-Prot

Q9QZH2

UniProtKB/TrEMBL

A0A8I6A6U6

Related

ENSRNOP00000088768.1, ENSRNOT00000119929.2

Conserved Domains (5) summary

sd00045
Location:417 → 454

ANK; ANK repeat [structural motif]

cd17720
Location:635 → 735

BRCT_Bard1_rpt2; second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

cd17734
Location:534 → 610

BRCT_Bard1_rpt1; first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

pfam12796
Location:400 → 487

Ank_2; Ankyrin repeats (3 copies)

pfam14835
Location:35 → 99

zf-RING_6; zf-RING of BARD1-type protein
XM_039084173.2 → XP_038940101.1 BRCA1-associated RING domain protein 1 isoform X1

UniProtKB/Swiss-Prot

Q9QZH2

Conserved Domains (5) summary

sd00045
Location:417 → 448

ANK; ANK repeat [structural motif]

cd17720
Location:661 → 761

BRCT_Bard1_rpt2; second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

cd17734
Location:560 → 636

BRCT_Bard1_rpt1; first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

pfam12796
Location:422 → 514

Ank_2; Ankyrin repeats (3 copies)

pfam14835
Location:35 → 99

zf-RING_6; zf-RING of BARD1-type protein
XM_063267689.1 → XP_063123759.1 BRCA1-associated RING domain protein 1 isoform X6