Ralb v-ral simian leukemia viral oncogene B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ralbprovided by MGI
Official Full Name: v-ral simian leukemia viral oncogene Bprovided by MGI
Primary source: MGI:MGI:1927244
See related: Ensembl:ENSMUSG00000004451 AllianceGenome:MGI:1927244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730472O18Rik
Summary: Predicted to enable GTPase activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; cellular response to exogenous dsRNA; and positive regulation of autophagosome assembly. Predicted to be located in midbody. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and skin. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALB (RAS like proto-oncogene B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 48.8), large intestine adult (RPKM 23.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.29 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (119398035..119432512, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (119470305..119504782, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

While lack of only one Ral GTPase was dispensable for early peripheral nerve development, ablation of both RalA and RalB resulted in persistent radial sorting defects, associated with hallmarks of deficits in Schwann cell process formation and maintenance.
Title: Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system.
Ablation of both RalA and RalB (but not individually) in Schwann cell resulted in impaired axon remyelination and target reinnervation following nerve injury, which resulted in slowed recovery of motor function.
Title: RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation.
Platelet Ral GTPases primarily control P-selectin surface expression, in turn regulating platelet-leukocyte interaction.
Title: Mouse Platelet Ral GTPases Control P-Selectin Surface Expression, Regulating Platelet-Leukocyte Interaction.
This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells.
Title: Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB.
Title: Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.
findings show either RALA or RALB is sufficient for tumor growth; either RALA or RALB is sufficient for cell proliferation; RALA and RALB act in a redundant fashion
Title: Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis.
Endogenous RalB plays a negative role in the ingestion process of Fc gamma receptor-mediated macrophage phagocytosis.
Title: Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit27 (e-PCR), detects polymorphism
- UniSTS:128618

NoName (e-PCR)
- UniSTS:234196

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocyst assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocyst assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of exocyst localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocyst localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ras-related protein Ral-B

Names: v-ral simian leukemia viral oncogene homolog B (ras related)

NP_071722.1

EC 3.6.5.2

XP_006529845.1

EC 3.6.5.2

XP_036008626.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022327.5 → NP_071722.1 ras-related protein Ral-B

See identical proteins and their annotated locations for NP_071722.1

Status: VALIDATED

Source sequence(s)

AK033193, AK159993, BE943587, BY237628

Consensus CDS

CCDS15225.1

UniProtKB/Swiss-Prot

Q3TVS5, Q9JIW9

UniProtKB/TrEMBL

Q8CCG5

Related

ENSMUSP00000004565.9, ENSMUST00000004565.15

Conserved Domains (1) summary

cd04139
Location:15 → 178

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

119398035..119432512 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529782.3 → XP_006529845.1 ras-related protein Ral-B isoform X1

See identical proteins and their annotated locations for XP_006529845.1

UniProtKB/Swiss-Prot

Q3TVS5, Q9JIW9

UniProtKB/TrEMBL

Q8CCG5

Conserved Domains (1) summary

cd04139
Location:15 → 178

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
XM_036152733.1 → XP_036008626.1 ras-related protein Ral-B isoform X1

UniProtKB/Swiss-Prot

Q3TVS5, Q9JIW9

UniProtKB/TrEMBL

Q8CCG5

Conserved Domains (1) summary

cd04139
Location:15 → 178

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB