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    Nme6 NME/NM23 nucleoside diphosphate kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58964, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nme6provided by RGD
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 6provided by RGD
    Primary source
    RGD:61896
    See related
    EnsemblRapid:ENSRNOG00000020721 AllianceGenome:RGD:61896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nm23-R6
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 47.8), Heart (RPKM 44.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nme6 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118708092..118717756)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109832085..109839301)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117920912..117928148)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6C, pseudogene 2 Neighboring gene F-box and WD repeat domain containing 12 Neighboring gene serine peptidase inhibitor, Kazal type 8 Neighboring gene cathelicidin antimicrobial peptide Neighboring gene cell division cycle 25A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nucleoside diphosphate kinase 6
    Names
    NDK 6
    NDP kinase 6
    expressed in non-metastatic cells 6 (nucleoside-diphosphate kinase)
    expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase)
    non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
    nucleoside diphosphate kinase type 6
    NP_001178813.1
    XP_006243909.1
    XP_006243910.1
    XP_006243911.1
    XP_006243912.1
    XP_006243913.1
    XP_017451369.1
    XP_038937966.1
    XP_038937967.1
    XP_038937969.1
    XP_063122119.1
    XP_063122120.1
    XP_063122121.1
    XP_063122122.1
    XP_063122123.1
    XP_063122125.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191884.2NP_001178813.1  nucleoside diphosphate kinase 6

      See identical proteins and their annotated locations for NP_001178813.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C2, R9PXW5
      Conserved Domains (2) summary
      smart00562
      Location:12149
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04414
      Location:12146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
    2. NM_001431584.1NP_001418513.1  nucleoside diphosphate kinase 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C2, R9PXW5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118708092..118717756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243849.3XP_006243911.1  nucleoside diphosphate kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006243911.1

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C2, R9PXW5
      Conserved Domains (2) summary
      smart00562
      Location:12149
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04414
      Location:12146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
    2. XM_006243848.5XP_006243910.1  nucleoside diphosphate kinase 6 isoform X1

      Conserved Domains (2) summary
      smart00562
      Location:12149
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04414
      Location:12146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
    3. XM_063266051.1XP_063122121.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
    4. XM_006243847.5XP_006243909.1  nucleoside diphosphate kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006243909.1

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C2, R9PXW5
      Conserved Domains (2) summary
      smart00562
      Location:12149
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04414
      Location:12146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
    5. XM_063266050.1XP_063122120.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
    6. XM_039082039.2XP_038937967.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
      Conserved Domains (1) summary
      cl00335
      Location:1101
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    7. XM_063266049.1XP_063122119.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
    8. XM_039082038.2XP_038937966.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
      Conserved Domains (1) summary
      cl00335
      Location:1101
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    9. XM_006243850.5XP_006243912.1  nucleoside diphosphate kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006243912.1

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C2, R9PXW5
      Conserved Domains (2) summary
      smart00562
      Location:12149
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04414
      Location:12146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
    10. XM_063266055.1XP_063122125.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
    11. XM_039082041.2XP_038937969.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
      Conserved Domains (1) summary
      cl00335
      Location:1101
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    12. XM_006243851.4XP_006243913.1  nucleoside diphosphate kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006243913.1

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C2, R9PXW5
      Related
      ENSRNOP00000028125.6, ENSRNOT00000028125.9
      Conserved Domains (2) summary
      smart00562
      Location:12149
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04414
      Location:12146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
    13. XM_063266053.1XP_063122123.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
    14. XM_063266052.1XP_063122122.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
    15. XM_017595880.3XP_017451369.1  nucleoside diphosphate kinase 6 isoform X2

      UniProtKB/Swiss-Prot
      O88426
      UniProtKB/TrEMBL
      A6I3C3
      Conserved Domains (1) summary
      cl00335
      Location:1101
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...