pbx2 pre-B-cell leukemia homeobox 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pbx2provided by ZNC
Official Full Name: pre-B-cell leukemia homeobox 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000405-5
See related: Ensembl:ENSDARG00000019717 AllianceGenome:ZFIN:ZDB-GENE-000405-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pbxy; wu:fb73g03
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic retina morphogenesis in camera-type eye; midbrain development; and striated muscle cell differentiation. Predicted to be active in nucleus. Orthologous to human PBX2 (PBX homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (48616220..48643191)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (48674163..48701173)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A loss of Pbx2 and Pbx4 causes a significant reduction of hindbrain and spinal cord expression of lbx1 genes.
Title: Pbx-dependent regulation of lbx gene expression in developing zebrafish embryos.
These data define a novel role for Pbx2 in patterning the vertebrate retina and tectum in a manner required for proper retinal ganglion cell axon outgrowth
Title: Pbx homeodomain proteins pattern both the zebrafish retina and tectum.
eliminating zebrafish Lzr/Pbx4 and Pbx2 function prevents hindbrain segmentation and causes a wholesale anterior homeotic transformation of r2-r6, to r1 identity
Title: Eliminating zebrafish pbx proteins reveals a hindbrain ground state.

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General gene information

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Markers

fc16c08.y1 (e-PCR)
- UniSTS:192782

fb73g03.x1 (e-PCR)
- UniSTS:187453

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle fiber development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pre-B-cell leukemia transcription factor 2

Names: pre-B-cell leukemia transcription factor y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131612.2 → NP_571687.1 pre-B-cell leukemia transcription factor 2

See identical proteins and their annotated locations for NP_571687.1

Status: VALIDATED

Source sequence(s)

CABZ01051477, CU694532

UniProtKB/TrEMBL

A0A8M1PBQ4, F1QZK8, Q9I9B4

Related

ENSDARP00000018156.5, ENSDART00000004751.7

Conserved Domains (2) summary

cd00086
Location:253 → 313

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam03792
Location:59 → 251

PBC; PBC domain