U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CCDC181 coiled-coil domain containing 181 [ Homo sapiens (human) ]

    Gene ID: 57821, updated on 10-Dec-2024

    Summary

    Official Symbol
    CCDC181provided by HGNC
    Official Full Name
    coiled-coil domain containing 181provided by HGNC
    Primary source
    HGNC:HGNC:28051
    See related
    Ensembl:ENSG00000117477 MIM:620891; AllianceGenome:HGNC:28051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf114
    Summary
    Predicted to enable microtubule binding activity. Predicted to be located in manchette and sperm flagellum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 7.3), kidney (RPKM 1.3) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCDC181 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169394870..169460669, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (168750193..168816015, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169364108..169429907, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169074345-169074918 Neighboring gene Sharpr-MPRA regulatory region 5967 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169076065-169076637 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:169082217-169083416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:169085415-169086034 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2070 Neighboring gene NME/NM23 family member 7 Neighboring gene NANOG hESC enhancer GRCh37_chr1:169185155-169185723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169225944-169226549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169226550-169227154 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:169336872-169338071 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1546 Neighboring gene Sharpr-MPRA regulatory region 5964 Neighboring gene solute carrier family 19 member 2 Neighboring gene MPRA-validated peak447 silencer Neighboring gene MPRA-validated peak448 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1250 Neighboring gene MPRA-validated peak449 silencer Neighboring gene Sharpr-MPRA regulatory region 2803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:169555193-169555694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:169555695-169556194 Neighboring gene coagulation factor V

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25846

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in manchette ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 181

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300968.1NP_001287897.1  coiled-coil domain-containing protein 181 isoform a

      See identical proteins and their annotated locations for NP_001287897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK313598, AL049687, BG206257
      Consensus CDS
      CCDS1279.1
      UniProtKB/TrEMBL
      B2R917
      Related
      ENSP00000442297.1, ENST00000545005.5
      Conserved Domains (1) summary
      pfam13904
      Location:338460
      DUF4207; Domain of unknown function (DUF4207)
    2. NM_001300969.2NP_001287898.1  coiled-coil domain-containing protein 181 isoform b

      See identical proteins and their annotated locations for NP_001287898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is longer than isoform a.
      Source sequence(s)
      AK223354, AL049687, BC026073, BG206257
      Consensus CDS
      CCDS72979.1
      UniProtKB/Swiss-Prot
      O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
      UniProtKB/TrEMBL
      B2R917
      Related
      ENSP00000356780.3, ENST00000367806.8
      Conserved Domains (1) summary
      pfam17380
      Location:338500
      DUF5401; Family of unknown function (DUF5401)
    3. NM_001394007.1NP_001380936.1  coiled-coil domain-containing protein 181 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL021068
      Consensus CDS
      CCDS72979.1
      UniProtKB/Swiss-Prot
      O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
      UniProtKB/TrEMBL
      B2R917
      Conserved Domains (1) summary
      pfam17380
      Location:338500
      DUF5401; Family of unknown function (DUF5401)
    4. NM_001394008.1NP_001380937.1  coiled-coil domain-containing protein 181 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL021068
      Consensus CDS
      CCDS1279.1
      UniProtKB/TrEMBL
      B2R917
    5. NM_001394009.1NP_001380938.1  coiled-coil domain-containing protein 181 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL021068
      UniProtKB/TrEMBL
      X6RJ50
      Related
      ENST00000491570.2
    6. NM_021179.3NP_067002.1  coiled-coil domain-containing protein 181 isoform a

      See identical proteins and their annotated locations for NP_067002.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AL049687, BC026073, BG206257
      Consensus CDS
      CCDS1279.1
      UniProtKB/TrEMBL
      B2R917
      Related
      ENSP00000356779.3, ENST00000367805.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      169394870..169460669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245383.1XP_005245440.1  coiled-coil domain-containing protein 181 isoform X1

      See identical proteins and their annotated locations for XP_005245440.1

      UniProtKB/Swiss-Prot
      O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
      UniProtKB/TrEMBL
      B2R917
      Conserved Domains (1) summary
      pfam17380
      Location:338500
      DUF5401; Family of unknown function (DUF5401)
    2. XM_017001938.2XP_016857427.1  coiled-coil domain-containing protein 181 isoform X1

      UniProtKB/Swiss-Prot
      O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
      UniProtKB/TrEMBL
      B2R917
      Conserved Domains (1) summary
      pfam17380
      Location:338500
      DUF5401; Family of unknown function (DUF5401)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      168750193..168816015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337933.1XP_054193908.1  coiled-coil domain-containing protein 181 isoform X1

      UniProtKB/TrEMBL
      B2R917
    2. XM_054337932.1XP_054193907.1  coiled-coil domain-containing protein 181 isoform X1

      UniProtKB/TrEMBL
      B2R917