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    RANBP10 RAN binding protein 10 [ Homo sapiens (human) ]

    Gene ID: 57610, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RANBP10provided by HGNC
    Official Full Name
    RAN binding protein 10provided by HGNC
    Primary source
    HGNC:HGNC:29285
    See related
    Ensembl:ENSG00000141084 MIM:614031; AllianceGenome:HGNC:29285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.1), endometrium (RPKM 6.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RANBP10 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67723070..67806560, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73517838..73601583, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67756973..67840463, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10979 Neighboring gene chromosome 16 open reading frame 86 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67710969-67711925 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67711926-67712881 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:67717419-67718618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10980 Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:67743233-67744011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67744012-67744789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7624 Neighboring gene Sharpr-MPRA regulatory region 12647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67839586-67840206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67840207-67840826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7626 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67851021-67851203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67859393-67860253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67876439-67877185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10990 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Ran-binding protein facilitates nuclear import of human papillomavirus type 16. Lai KY, et al. PLoS Pathog, 2021 May. PMID 33974675, Free PMC Article
    2. miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease. Her LS, et al. Theranostics, 2017. PMID 28744327, Free PMC Article
    3. Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication. Sato Y, et al. J Virol, 2016 Jan 6. PMID 26739050, Free PMC Article
    4. RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway. Hou J, et al. Cell Death Dis, 2021 Oct 20. PMID 34671019, Free PMC Article
    5. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Wang D, et al. Biochem Biophys Res Commun, 2004 Jan 9. PMID 14684163

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway.
      Title: RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway.
    2. A Ran-binding protein facilitates nuclear import of human papillomavirus type 16.
      Title: A Ran-binding protein facilitates nuclear import of human papillomavirus type 16.
    3. Authors provide evidence that enhancement of neuronal morphology through RANBP10 is one of the neuroprotective mechanisms for miR-196a.
      Title: miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease.
    4. The results showed that ICP0 interacted with cell protein RanBP10, a known transcriptional coactivator, in human herpesvirus 1-infected cells.
      Title: Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication.
    5. data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma
      Title: Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.
    6. RanBP10 might serve as a molecular link between Ran and noncentrosomal microtubules
      Title: RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31165, KIAA1464

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ran-binding protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320238.2 → NP_001307167.1  ran-binding protein 10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon and uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AI275875, AK295530, AY337313
      UniProtKB/Swiss-Prot
      Q6VN20
      Conserved Domains (5) summary
      smart00667
      Location:140 → 167
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:174 → 230
      CTLH; C-terminal to LisH motif
      smart00757
      Location:420 → 517
      CRA; CT11-RanBPM
      pfam10607
      Location:174 → 228
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:1 → 102
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    2. NM_001320239.2 → NP_001307168.1  ran-binding protein 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI275875, AK298806, AY337313
      Consensus CDS
      CCDS81999.1
      UniProtKB/Swiss-Prot
      Q6VN20
      Related
      ENSP00000392808.2, ENST00000448631.6
      Conserved Domains (5) summary
      smart00667
      Location:201 → 228
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:235 → 291
      CTLH; C-terminal to LisH motif
      smart00757
      Location:481 → 578
      CRA; CT11-RanBPM
      pfam10607
      Location:235 → 289
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cl02614
      Location:77 → 163
      SPRY; SPRY domain

    3. NM_001320240.2 → NP_001307169.1  ran-binding protein 10 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains three alternate internal exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AI275875, AK055727, AY337313
      UniProtKB/TrEMBL
      B3KP49
      Conserved Domains (4) summary
      smart00667
      Location:28 → 55
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:62 → 118
      CTLH; C-terminal to LisH motif
      smart00757
      Location:278 → 375
      CRA; CT11-RanBPM
      pfam10607
      Location:62 → 116
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    4. NM_001410883.1 → NP_001397812.1  ran-binding protein 10 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC010530, AC040162
      Consensus CDS
      CCDS92180.1
      UniProtKB/TrEMBL
      R4GMX8
      Related
      ENSP00000473396.1, ENST00000602677.5

    5. NM_020850.3 → NP_065901.1  ran-binding protein 10 isoform 1

      See identical proteins and their annotated locations for NP_065901.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI275875, AY337313
      Consensus CDS
      CCDS32469.1
      UniProtKB/Swiss-Prot
      A4FTY2, B4DID0, B4DQH9, E7EW27, Q6VN20, Q9P264
      Related
      ENSP00000316589.3, ENST00000317506.8
      Conserved Domains (5) summary
      smart00667
      Location:257 → 284
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:291 → 347
      CTLH; C-terminal to LisH motif
      smart00757
      Location:507 → 604
      CRA; CT11-RanBPM
      pfam10607
      Location:291 → 345
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:77 → 219
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67723070..67806560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434407.1 → XP_047290363.1  ran-binding protein 10 isoform X1

    2. XM_047434409.1 → XP_047290365.1  ran-binding protein 10 isoform X4

    3. XM_011523247.4 → XP_011521549.1  ran-binding protein 10 isoform X4

      See identical proteins and their annotated locations for XP_011521549.1

      Conserved Domains (4) summary
      smart00667
      Location:28 → 55
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:62 → 118
      CTLH; C-terminal to LisH motif
      smart00757
      Location:308 → 405
      CRA; CT11-RanBPM
      pfam10607
      Location:62 → 116
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    4. XM_006721238.5 → XP_006721301.1  ran-binding protein 10 isoform X2

      Conserved Domains (3) summary
      smart00668
      Location:135 → 191
      CTLH; C-terminal to LisH motif
      smart00757
      Location:381 → 478
      CRA; CT11-RanBPM
      pfam10607
      Location:135 → 189
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    5. XM_047434408.1 → XP_047290364.1  ran-binding protein 10 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73517838..73601583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313560.1 → XP_054169535.1  ran-binding protein 10 isoform X1

    2. XM_054313564.1 → XP_054169539.1  ran-binding protein 10 isoform X4

    3. XM_054313563.1 → XP_054169538.1  ran-binding protein 10 isoform X4

    4. XM_054313561.1 → XP_054169536.1  ran-binding protein 10 isoform X2

    5. XM_054313562.1 → XP_054169537.1  ran-binding protein 10 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VN20.1 GenPept UniProtKB/Swiss-Prot:Q6VN20

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