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    CG17636 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740847, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG17636provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025837
    Locus tag
    Dmel_CG17636
    See related
    AllianceGenome:FB:FBgn0025837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17636; EG:23E12.1
    Summary
    Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17636 in Genome Data Viewer
    Location:
    1A1-1A1; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (124370..126714, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20757..23101, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR40469 Neighboring gene Rho GTPase activating protein at 1A Neighboring gene mir-4915 stem loop Neighboring gene long non-coding RNA:CR45473 Neighboring gene trynity

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis. Brattig-Correia R, et al. Elife, 2024 Oct 10. PMID 39388236, Free PMC Article
    2. Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila. Lee SK, et al. Nat Commun, 2018 Nov 23. PMID 30470739, Free PMC Article
    3. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article
    4. An analysis of genetic changes during the divergence of Drosophila species. Sousa-Neves R, et al. PLoS One, 2010 May 5. PMID 20463966, Free PMC Article
    5. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Benos PV, et al. Genome Res, 2001 May. PMID 11337470, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17636-PA
    CG17636-PB
    CG17636-PC
    NP_001096854.1
    NP_001245441.1
    NP_001245442.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      124370..126714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103384.3 → NP_001096854.1  uncharacterized protein Dmel_CG17636, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZS5
      Conserved Domains (1) summary
      pfam01019
      Location:55 → 560
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. NM_001258513.2 → NP_001245442.1  uncharacterized protein Dmel_CG17636, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245442.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFP5
      Conserved Domains (1) summary
      pfam01019
      Location:69 → 574
      G_glu_transpept; Gamma-glutamyltranspeptidase

    3. NM_001258512.2 → NP_001245441.1  uncharacterized protein Dmel_CG17636, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5A7L0
      Conserved Domains (1) summary
      pfam01019
      Location:1 → 490
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5A7L0 D5A7L0
    M9NFP5 M9NFP5
    Q9XZS5 Q9XZS5

    Gene LinkOut

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