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    kank2 KN motif and ankyrin repeat domains 2 [ Danio rerio (zebrafish) ]

    Gene ID: 571549, updated on 4-Jan-2025

    Summary

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    Official Symbol
    kank2provided by ZNC
    Official Full Name
    KN motif and ankyrin repeat domains 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-121
    See related
    Ensembl:ENSDARG00000018393 AllianceGenome:ZFIN:ZDB-GENE-040724-121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dZ118J2.12; si:ch73-108m21.1; si:busm1-118j2.12
    Summary
    Acts upstream of or within glomerular basement membrane development and podocyte development. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in head; nervous system; pectoral fin; segmental plate; and trunk. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16 and palmoplantar keratoderma and woolly hair. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See kank2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (55154603..55213981, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54907025..54959426, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hemoglobin, alpha embryonic 1.3 Neighboring gene hemoglobin alpha embryonic-3 Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin like 8 Neighboring gene uncharacterized LOC101884549

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. Gee HY, et al. J Clin Invest, 2015 Jun. PMID 25961457, Free PMC Article
    2. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Boggetti B, et al. Dev Biol, 2012 May 1. PMID 22387208
    3. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Hensley MR, et al. Sci Rep, 2016 Jun 13. PMID 27292017, Free PMC Article
    4. The timing of Timezyme diversification in vertebrates. Cazaméa-Catalan D, et al. PLoS One, 2014. PMID 25486407, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glomerular basement membrane development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of vitamin D receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305620.1 → NP_001292549.1  KN motif and ankyrin repeat domain-containing protein 2

      See identical proteins and their annotated locations for NP_001292549.1

      Status: VALIDATED

      Source sequence(s)
      CU464181
      UniProtKB/Swiss-Prot
      X1WE18
      UniProtKB/TrEMBL
      A0A8M9PIR3
      Related
      ENSDARP00000146055.1, ENSDART00000179903.1
      Conserved Domains (5) summary
      cd00204
      Location:890 → 1021
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:895 → 964
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:34 → 72
      KN_motif; KN motif
      pfam12796
      Location:1005 → 1059
      Ank_2; Ankyrin repeats (3 copies)
      cl25496
      Location:607 → 899
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      55154603..55213981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164339.5 → XP_005164396.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005164396.1

      UniProtKB/Swiss-Prot
      X1WE18
      UniProtKB/TrEMBL
      A0A8M9PIR3
      Related
      ENSDARP00000128469.1, ENSDART00000154031.2
      Conserved Domains (5) summary
      cd00204
      Location:890 → 1021
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:895 → 964
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:34 → 72
      KN_motif; KN motif
      pfam12796
      Location:1005 → 1059
      Ank_2; Ankyrin repeats (3 copies)
      cl25496
      Location:607 → 899
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. XM_021471168.2 → XP_021326843.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      X1WE18
      UniProtKB/TrEMBL
      A0A8M9PIR3
      Conserved Domains (5) summary
      cd00204
      Location:890 → 1021
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:895 → 964
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:34 → 72
      KN_motif; KN motif
      pfam12796
      Location:1005 → 1059
      Ank_2; Ankyrin repeats (3 copies)
      cl25496
      Location:607 → 899
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    X1WE18.1 GenPept UniProtKB/Swiss-Prot:X1WE18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials