dapk2a death-associated protein kinase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dapk2aprovided by ZNC
Official Full Name: death-associated protein kinase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080402-8
See related: Ensembl:ENSDARG00000061096 AllianceGenome:ZFIN:ZDB-GENE-080402-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dapk2; zgc:171281
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and positive regulation of apoptotic process. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human DAPK2 (death associated protein kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (29278579..29292206, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (29007429..29027580, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: death-associated protein kinase 2a

Names: death-associated protein kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123064.2 → NP_001116536.2 death-associated protein kinase 2a

See identical proteins and their annotated locations for NP_001116536.2

Status: VALIDATED

Source sequence(s)

CR352249

UniProtKB/TrEMBL

A0A8M1NG25, E7F1A1

Related

ENSDARP00000081187.4, ENSDART00000086753.7

Conserved Domains (2) summary

smart00220
Location:13 → 275

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:7 → 275

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

29278579..29292206 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477584.2 → XP_021333259.1 death-associated protein kinase 2a isoform X1

UniProtKB/TrEMBL

A0A8M9Q7Z0

Conserved Domains (1) summary

cl21453
Location:1 → 198

PKc_like; Protein Kinases, catalytic domain