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    wnk3 WNK lysine deficient protein kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 567408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wnk3provided by ZNC
    Official Full Name
    WNK lysine deficient protein kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090312-81
    See related
    AllianceGenome:ZFIN:ZDB-GENE-090312-81
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wnk3l; wnk3-like; im:7152756; si:dkey-151g10.3
    Summary
    Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; monoatomic ion homeostasis; and regulation of metal ion transport. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Prieto syndrome. Orthologous to human WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wnk3 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (25151153..25225747)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (25224395..25299200)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene erb-b2 receptor tyrosine kinase 3b Neighboring gene proliferation-associated 2G4, b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. Lai JG, et al. PLoS One, 2014. PMID 25171174, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase WNK3; serine/threonine-protein kinase WNK1
    XP_009295201.2
    XP_009295202.2
    XP_009295203.2
    XP_009295204.2
    XP_021325641.1
    XP_021325642.1
    XP_021325643.1
    XP_021325644.1
    XP_021325645.1
    XP_068075160.1
    XP_695795.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      25151153..25225747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469966.2 → XP_021325641.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PTI7
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    2. XM_021469967.2 → XP_021325642.1  serine/threonine-protein kinase WNK1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P5H4
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    3. XM_021469970.2 → XP_021325645.1  serine/threonine-protein kinase WNK3 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PWV5
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    4. XM_021469968.2 → XP_021325643.1  serine/threonine-protein kinase WNK3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PFG8
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    5. XM_021469969.2 → XP_021325644.1  serine/threonine-protein kinase WNK1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PL63
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395152.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      52346..129233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296926.4 → XP_009295201.2  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AVG7
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    2. XM_690703.10 → XP_695795.7  serine/threonine-protein kinase WNK1 isoform X2

      UniProtKB/TrEMBL
      A0A8N7TFG0
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    3. XM_009296929.4 → XP_009295204.2  serine/threonine-protein kinase WNK3 isoform X5

      UniProtKB/TrEMBL
      A0A8M3ANR2
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    4. XM_009296927.4 → XP_009295202.2  serine/threonine-protein kinase WNK3 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AN04
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    5. XM_009296928.4 → XP_009295203.2  serine/threonine-protein kinase WNK1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B680
      Conserved Domains (2) summary
      cd14031
      Location:190 → 464
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:480 → 517
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    6. XM_068219059.1 → XP_068075160.1  serine/threonine-protein kinase WNK1 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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