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    PSG5 pregnancy specific beta-1-glycoprotein 5 [ Homo sapiens (human) ]

    Gene ID: 5673, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PSG5provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 5provided by HGNC
    Primary source
    HGNC:HGNC:9522
    See related
    Ensembl:ENSG00000204941 MIM:176394; AllianceGenome:HGNC:9522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSG; FL-NCA-3
    Summary
    The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 117.8) See more
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    Genomic context

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    See PSG5 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43167743..43186536, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45988311..46007149, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43671895..43690688, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 2 Neighboring gene CEA cell adhesion molecule pseudogene 9 Neighboring gene PSG11, PSG2 and PSG5 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 9 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 4 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of a pregnancy-specific beta 1 glycoprotein gene family member. Identification of a functional promoter region and several putative regulatory sequences. Panzetta-Dutari GM, et al. Mol Biol Rep, 1992 Sep. PMID 1454058
    2. PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. Camolotto SA, et al. PLoS One, 2013. PMID 23418492, Free PMC Article
    3. Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1. Blanchon L, et al. Biochem Biophys Res Commun, 2006 May 12. PMID 16563348
    4. Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women. Okazaki S, et al. Obstet Gynecol, 2007 Nov. PMID 17978129
    5. Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS beta G/FL-NCA glycoprotein with a novel domain arrangement. Khan WN, et al. Biochem Biophys Res Commun, 1989 Jun 15. PMID 2735907

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. show that human PSG1 binds alphaIIbbeta3 and inhibits the platelet - fibrinogen interaction. Unexpectedly, however, the KGD is not critical as multiple PSG1 domains independently bind and inhibit alphaIIbbeta3 function
      Title: Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction.
    2. esults are consistent with a regulatory role of lysine acetylation on PSG expression through a relaxed chromatin state and an increase in the transcriptional activity of Sp1 and KLF6 following an augmented Sp1 acetylation and KLF6 nuclear localization.
      Title: PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins.
    3. the mRNA expression of PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN is up-regulated in cells circulating within blood from women with preeclampsia, and is positively correlated with cliical severity
      Title: Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women.
    4. Strong synergic activity of KLF4 and Sp1 on the PSG-5 promoter.
      Title: Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific beta-1-glycoprotein 5
    Names
    PS-beta-G-5
    PSBG-5
    Pregnancy-specific beta-1-glycoprotein-5
    fetal liver non-specific cross-reactive antigen 3
    pregnancy-specific beta 1 glycoprotein
    pregnancy-specific glycoprotein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130014.2 → NP_001123486.1  pregnancy-specific beta-1-glycoprotein 5 precursor

      See identical proteins and their annotated locations for NP_001123486.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 3' exon, as compared to variant 1.
      Source sequence(s)
      AA151017, BC012607, BG622527, DA835167, M25384, M73713
      Consensus CDS
      CCDS12617.1
      UniProtKB/Swiss-Prot
      Q15238, Q15239, Q96QJ1, Q9UQ75
      UniProtKB/TrEMBL
      E7EQY3
      Related
      ENSP00000386008.1, ENST00000407356.5
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246 → 320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242 → 320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    2. NM_002781.4 → NP_002772.3  pregnancy-specific beta-1-glycoprotein 5 precursor

      See identical proteins and their annotated locations for NP_002772.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012607, BG621332, BG622527, DA835167, M25384
      Consensus CDS
      CCDS12617.1
      UniProtKB/Swiss-Prot
      Q15238, Q15239, Q96QJ1, Q9UQ75
      UniProtKB/TrEMBL
      E7EQY3
      Related
      ENSP00000344413.6, ENST00000342951.11
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246 → 320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242 → 320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43167743..43186536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027003.2 → XP_016882492.1  pregnancy-specific beta-1-glycoprotein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q15238, Q15239, Q96QJ1, Q9UQ75
      UniProtKB/TrEMBL
      E7EQY3
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246 → 320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242 → 320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    2. XM_011527132.4 → XP_011525434.1  pregnancy-specific beta-1-glycoprotein 5 isoform X2

      Conserved Domains (1) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45988311..46007149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321490.1 → XP_054177465.1  pregnancy-specific beta-1-glycoprotein 5 isoform X1

    2. XM_054321491.1 → XP_054177466.1  pregnancy-specific beta-1-glycoprotein 5 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15238.3 GenPept UniProtKB/Swiss-Prot:Q15238

    Gene LinkOut

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