U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    arhgap44a Rho GTPase activating protein 44a [ Danio rerio (zebrafish) ]

    Gene ID: 567298, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    arhgap44aprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 44aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120215-49
    See related
    Ensembl:ENSDARG00000102424 AllianceGenome:ZFIN:ZDB-GENE-120215-49
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-114m9.1
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within positive regulation of GTPase activity and signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See arhgap44a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (48629891..48783055, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (44485052..44637673, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene nudE neurodevelopment protein 1-like 1b Neighboring gene ring finger protein 222 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a Neighboring gene uncharacterized LOC103910314

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    2. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rho GTPase-activating protein RICH2; rho GTPase-activating protein 44

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      48629891..48783055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299715.4 → XP_009297990.1  rho GTPase-activating protein 44 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AY97
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. XM_068219431.1 → XP_068075532.1  rho GTPase-activating protein 44 isoform X6

    3. XM_009299717.4 → XP_009297992.1  rho GTPase-activating protein 44 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q8P0
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. XM_009299714.4 → XP_009297989.1  rho GTPase-activating protein 44 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4C6
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    5. XM_021474728.2 → XP_021330403.1  rho GTPase-activating protein 44 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PTP9
      Conserved Domains (3) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      pfam14944
      Location:568 → 651
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    6. XM_009299719.4 → XP_009297994.1  rho GTPase-activating protein 44 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q4C8
      Conserved Domains (3) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      pfam14944
      Location:637 → 720
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    7. XM_021474727.2 → XP_021330402.1  rho GTPase-activating protein 44 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AQV7
      Related
      ENSDARP00000133509.2, ENSDART00000164979.2
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394537.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      76848..250711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471461.2 → XP_021327136.1  rho GTPase-activating protein 44 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PXV6
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    2. XM_021471465.2 → XP_021327140.1  rho GTPase-activating protein 44 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q4C8
      Conserved Domains (3) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      pfam14944
      Location:637 → 720
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    3. XM_021471464.2 → XP_021327139.1  rho GTPase-activating protein 44 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PQH5
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    4. XM_021471460.2 → XP_021327135.1  rho GTPase-activating protein 44 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q151
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    5. XM_021471463.2 → XP_021327138.1  rho GTPase-activating protein 44 isoform X3

      UniProtKB/TrEMBL
      A0A8M9P8I2
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    6. XM_021471462.2 → XP_021327137.1  rho GTPase-activating protein 44 isoform X3

      UniProtKB/TrEMBL
      A0A8M9P8I2
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    7. XM_068218115.1 → XP_068074216.1  rho GTPase-activating protein 44 isoform X8

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395228.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      5979..160803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473982.2 → XP_021329657.1  rho GTPase-activating protein 44 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AY97
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. XM_068219178.1 → XP_068075279.1  rho GTPase-activating protein 44 isoform X6

    3. XM_021473985.2 → XP_021329660.1  rho GTPase-activating protein 44 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q8P0
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. XM_021473981.2 → XP_021329656.1  rho GTPase-activating protein 44 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4C6
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    5. XM_021473987.2 → XP_021329662.1  rho GTPase-activating protein 44 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PTP9
      Conserved Domains (3) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      pfam14944
      Location:568 → 651
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    6. XM_021473986.2 → XP_021329661.1  rho GTPase-activating protein 44 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q4C8
      Conserved Domains (3) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      pfam14944
      Location:637 → 720
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    7. XM_021473984.2 → XP_021329659.1  rho GTPase-activating protein 44 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AQV7
      Conserved Domains (2) summary
      cd07619
      Location:13 → 265
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:254 → 454
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools