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    esyt1a extended synaptotagmin-like protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 567227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    esyt1aprovided by ZNC
    Official Full Name
    extended synaptotagmin-like protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090311-55
    See related
    Ensembl:ENSDARG00000034714 AllianceGenome:ZFIN:ZDB-GENE-090311-55
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-150a20.1
    Summary
    Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to act upstream of or within endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT1 (extended synaptotagmin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See esyt1a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (25308011..25349016)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (25381091..25420133)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-151g10.6 Neighboring gene proliferation-associated 2G4, b Neighboring gene uncharacterized LOC108181437 Neighboring gene formin-like 3 Neighboring gene low density lipoprotein receptor-related protein 1Ab Neighboring gene somatostatin receptor type 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article
    2. A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. Craxton M. BMC Genomics, 2010 Jan 15. PMID 20078875, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    extended synaptotagmin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      25308011..25349016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_690519.7 → XP_695611.3  extended synaptotagmin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8N7T801
      Related
      ENSDARP00000115119.1, ENSDART00000140463.2
      Conserved Domains (4) summary
      cd04030
      Location:950 → 1075
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:466 → 570
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:635 → 755
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:119 → 297
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395152.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      212198..232342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473695.2 → XP_021329370.1  extended synaptotagmin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q804
      Conserved Domains (2) summary
      cd08391
      Location:312 → 414
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      cl27773
      Location:119 → 297
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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