poln polymerase (DNA directed) nu [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: polnprovided by ZNC
Official Full Name: polymerase (DNA directed) nuprovided by ZNC
Primary source: ZFIN:ZDB-GENE-100917-1
See related: Ensembl:ENSDARG00000103961 AllianceGenome:ZFIN:ZDB-GENE-100917-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-11k2.4
Summary: Enables DNA polymerase activity. Acts upstream of or within DNA strand elongation and error-free translesion synthesis. Is expressed in testis. Orthologous to human POLN (DNA polymerase nu). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24391129..24453754)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24119972..24182597)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of POLN gene arrangement and expression in zebrafish
Title: Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN).

Submit: New GeneRIF Correction

General gene information

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Markers

fb93e07.x1 (e-PCR)
- UniSTS:203538

z57720 (e-PCR), detects polymorphism
- UniSTS:238699

fa10g02.s1 (e-PCR)
- UniSTS:189582

fd19a03.x1 (e-PCR)
- UniSTS:204233

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
NOT enables exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA strand elongation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within error-free translesion synthesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within translesion synthesis	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA polymerase nu

NP_001093496.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100026.1 → NP_001093496.1 DNA polymerase nu

See identical proteins and their annotated locations for NP_001093496.1

Status: PROVISIONAL

Source sequence(s)

DQ630550

UniProtKB/TrEMBL

A5X572

Related

ENSDARP00000099211.1, ENSDART00000108753.3

Conserved Domains (2) summary

cd08638
Location:723 → 1132

DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation

cl10012
Location:629 → 716

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily