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    wfikkn2a info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a [ Danio rerio (zebrafish) ]

    Gene ID: 564992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wfikkn2aprovided by ZNC
    Official Full Name
    info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120914-1
    See related
    Ensembl:ENSDARG00000013460 AllianceGenome:ZFIN:ZDB-GENE-120914-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Gasp1a; wfikkn2
    Summary
    Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in transforming growth factor beta receptor signaling pathway. Predicted to be active in extracellular space. Is expressed in hindbrain; pectoral fin bud; and post-vent region. Orthologous to human WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wfikkn2a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (18097625..18105178)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (17947587..17955124)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 26 Neighboring gene ankyrin repeat domain 40 Neighboring gene uncharacterized LOC137490521 Neighboring gene uncharacterized LOC108182810 Neighboring gene transducer of ERBB2, 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. GASP/WFIKKN proteins: evolutionary aspects of their functions. Monestier O, et al. PLoS One, 2012. PMID 22937083, Free PMC Article
    2. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
    Names
    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
    growth and differentiation associated serum protein 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      18097625..18105178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_688302.9 → XP_693394.5  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

      Related
      ENSDARP00000025648.7, ENSDART00000021634.8
      Conserved Domains (7) summary
      smart00131
      Location:325 → 375
      KU; BPTI/Kunitz family of serine protease inhibitors
      cd00104
      Location:137 → 173
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd03575
      Location:451 → 559
      NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
      pfam07679
      Location:209 → 303
      I-set; Immunoglobulin I-set domain
      pfam00014
      Location:382 → 433
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:43 → 89
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      cl11960
      Location:223 → 303
      Ig; Immunoglobulin domain
    Nucleotide Protein
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