prss23 serine protease 23 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prss23provided by ZNC
Official Full Name: serine protease 23provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9149
See related: Ensembl:ENSDARG00000055786 AllianceGenome:ZFIN:ZDB-GENE-030131-9149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb01h12; wu:fb01h12
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within atrioventricular valve development; endocardium morphogenesis; and regulation of Notch signaling pathway. Is expressed in atrioventricular canal; atrium; cardiac ventricle; and pectoral fin. Orthologous to human PRSS23 (serine protease 23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (30800839..30808174, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (30462035..30468042, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

deficiency of PRSS23 in zebrafish embryos inhibited the initiation of the endothelial to mesenchymal transition which resulted in atrioventricular canal malformation.
Title: PRSS23 is essential for the Snail-dependent endothelial-to-mesenchymal transition during valvulogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk97c04.x1 (e-PCR)
- UniSTS:201810

fb01h12.y1 (e-PCR)
- UniSTS:189801

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: serine protease 23

Names: protease, serine, 23; serine protease 23-like

NP_001410165.1

EC 3.4.21.-

XP_068069325.1

EC 3.4.21.-

XP_068069326.1

EC 3.4.21.-

XP_068069327.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.