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    arhgap12a Rho GTPase activating protein 12a [ Danio rerio (zebrafish) ]

    Gene ID: 563267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgap12aprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 12aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050809-38
    See related
    Ensembl:ENSDARG00000008548 AllianceGenome:ZFIN:ZDB-GENE-050809-38
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7153489; si:ch211-159p3.3
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in ectoderm. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See arhgap12a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (43749221..43797218)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (43896185..43944225)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 5B, a Neighboring gene finTRIM family, member 16 Neighboring gene zinc finger E-box binding homeobox 1a Neighboring gene NOD-like receptor family B, member 5 Neighboring gene guanylate binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
    2. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Kimelman D, et al. Elife, 2017 Dec 28. PMID 29283341, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 12a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126407.1 → NP_001119879.1  rho GTPase-activating protein 12a

      Status: PROVISIONAL

      Source sequence(s)
      CR457482
      UniProtKB/TrEMBL
      A0A8M1NHD5, F6P057
      Related
      ENSDARP00000122140.1, ENSDART00000142804.3
      Conserved Domains (6) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:638 → 824
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:448 → 558
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:462 → 559
      PH; PH domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      43749221..43797218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480748.2 → XP_021336423.1  rho GTPase-activating protein 12a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QA49
      Conserved Domains (5) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:660 → 846
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:470 → 580
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    2. XM_005171385.5 → XP_005171442.1  rho GTPase-activating protein 12a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BIT3
      Conserved Domains (6) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:632 → 818
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:442 → 552
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:456 → 553
      PH; PH domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    3. XM_005171386.5 → XP_005171443.1  rho GTPase-activating protein 12a isoform X4

      UniProtKB/TrEMBL
      A0A8M2BIQ0
      Conserved Domains (6) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:610 → 796
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:420 → 530
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:434 → 531
      PH; PH domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    4. XM_021480763.2 → XP_021336438.1  rho GTPase-activating protein 12a isoform X3

      UniProtKB/TrEMBL
      A0A8M9QA59
      Conserved Domains (5) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:616 → 802
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:426 → 536
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    5. XM_005171388.5 → XP_005171445.1  rho GTPase-activating protein 12a isoform X5

      UniProtKB/TrEMBL
      A0A8M2BJ65
      Conserved Domains (6) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:588 → 774
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:398 → 508
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:412 → 509
      PH; PH domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    6. XM_021480770.2 → XP_021336445.1  rho GTPase-activating protein 12a isoform X6

      UniProtKB/TrEMBL
      A0A8M9QNP2
      Conserved Domains (5) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:583 → 769
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:393 → 503
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    7. XM_021480754.2 → XP_021336429.1  rho GTPase-activating protein 12a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QA49
      Conserved Domains (5) summary
      cd12070
      Location:11 → 70
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:660 → 846
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:470 → 580
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:252 → 278
      WW; WW domain
      pfam16618
      Location:67 → 233
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    Nucleotide Protein Strain
    Heading Accession and Version

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