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    lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [ Danio rerio (zebrafish) ]

    Gene ID: 560325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrig1provided by ZNC
    Official Full Name
    leucine-rich repeats and immunoglobulin-like domains 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031113-23
    See related
    Ensembl:ENSDARG00000075625 AllianceGenome:ZFIN:ZDB-GENE-031113-23
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb994; fc26a06; wu:fc26a06
    Summary
    Is expressed in axis; central nervous system; notochord; pharyngeal arch 3-7 skeleton; and somite. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lrig1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (16331824..16395892, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (16195141..16261257, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxymethylcytosine binding, ES cell specific Neighboring gene RAB7a, member RAS oncogene family Neighboring gene solute carrier family 25 member 26 Neighboring gene uncharacterized LOC137496682 Neighboring gene uncharacterized LOC137496683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional and evolutionary insights from the Ciona notochord transcriptome. Reeves WM, et al. Development, 2017 Sep 15. PMID 28928284, Free PMC Article
    2. BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. Knickmeyer MD, et al. Int J Mol Sci, 2021 Apr 27. PMID 33925390, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    leucine-rich repeats and immunoglobulin-like domains protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      16331824..16395892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224309.1 → XP_068080410.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    2. XM_683725.10 → XP_688817.4  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

      Related
      ENSDARP00000098283.2, ENSDART00000115085.4
      Conserved Domains (11) summary
      cd05763
      Location:607 → 681
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00408
      Location:698 → 761
      IGc2; Immunoglobulin C-2 Type
      smart00013
      Location:31 → 63
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:433 → 481
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:492 → 586
      IG_like; Immunoglobulin like
      cd00116
      Location:77 → 334
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:590 → 680
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:132 → 155
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:373 → 414
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:299 → 358
      LRR_8; Leucine rich repeat
      pfam13927
      Location:485 → 572
      Ig_3; Immunoglobulin domain

    3. XM_068224310.1 → XP_068080411.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X3

    4. XM_068224311.1 → XP_068080412.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X4

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395297.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      242955..257723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474233.2 → XP_021329908.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X5

      Conserved Domains (3) summary
      cd05763
      Location:91 → 165
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      pfam07679
      Location:168 → 255
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:5 → 70
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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