aggf1 angiogenic factor with G patch and FHA domains 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aggf1provided by ZNC
Official Full Name: angiogenic factor with G patch and FHA domains 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-836
See related: Ensembl:ENSDARG00000060109 AllianceGenome:ZFIN:ZDB-GENE-060929-836
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7146636; zgc:152959
Summary: Predicted to enable nucleic acid binding activity. Acts upstream of or within blood vessel development; hemangioblast cell differentiation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Is expressed in several structures, including blastomere; brain; cardiovascular system; head; and liver. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (7741780..7781720, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (8004112..8031214, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling.
Title: Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling.
Bmp-induced activation of beta-catenin through Aggf1 regulates caudal vein development by promoting the Nr2f2-dependent differentiation of venous endothelial cells and their survival.
Title: β-Catenin-dependent transcription is central to Bmp-mediated formation of venous vessels.
aggf1 is involved in differentiation of both hematopoietic and endothelial lineages and acts upstream of scl, fli1, and etsrp in specification of hemangioblasts
Title: Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish.
Our study establishes AGGF1 as an angiogenic factor with an important role in the specification of vein identity and suggests that AGGF1-mediated AKT signaling is responsible for establishing venous cell fate
Title: Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemangioblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within venous blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: angiogenic factor with G patch and FHA domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079982.1 → NP_001073451.1 angiogenic factor with G patch and FHA domains 1

See identical proteins and their annotated locations for NP_001073451.1

Status: PROVISIONAL

Source sequence(s)

BC124193

UniProtKB/TrEMBL

Q08CK9

Related

ENSDARP00000146953.1, ENSDART00000189131.1

Conserved Domains (5) summary

COG1716
Location:491 → 570

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:469 → 574

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam01585
Location:677 → 718

G-patch; G-patch domain

cd16164
Location:211 → 264

OCRE_VG5Q; OCRE domain found in angiogenic factor VG5Q and similar proteins

cl24005
Location:41 → 108

DUF2570; Protein of unknown function (DUF2570)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

7741780..7781720 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468864.2 → XP_021324539.1 angiogenic factor with G patch and FHA domains 1 isoform X1

UniProtKB/TrEMBL

A0A8M9PIC1

Conserved Domains (4) summary

cd00060
Location:470 → 575

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd16164
Location:211 → 264

OCRE_VG5Q; OCRE domain found in angiogenic factor VG5Q and similar proteins

pfam01585
Location:685 → 726

G-patch; G-patch domain

cl26953
Location:13 → 149

HSP70; Hsp70 protein
XM_021468865.2 → XP_021324540.1 angiogenic factor with G patch and FHA domains 1 isoform X2

UniProtKB/TrEMBL

A0A8M9PTY3

Conserved Domains (4) summary

cd00060
Location:336 → 441

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd16164
Location:211 → 264

OCRE_VG5Q; OCRE domain found in angiogenic factor VG5Q and similar proteins

pfam01585
Location:551 → 592

G-patch; G-patch domain

cl26953
Location:13 → 149

HSP70; Hsp70 protein