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    tox4a TOX high mobility group box family member 4 a [ Danio rerio (zebrafish) ]

    Gene ID: 559853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tox4aprovided by ZNC
    Official Full Name
    TOX high mobility group box family member 4 aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-576
    See related
    Ensembl:ENSDARG00000002031 AllianceGenome:ZFIN:ZDB-GENE-070912-576
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tox4; wu:fe15b11; si:dkey-75g22.1
    Summary
    Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tox4a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (38067510..38080656, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (38085347..38098528, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene calsequestrin 1a Neighboring gene si:rp71-1g18.1 Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene cerebellin 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of γδ T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Wan F, et al. Front Immunol, 2016. PMID 28119690, Free PMC Article
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0737

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TOX high mobility group box family member 4-A; epidermal Langerhans cell protein LCP1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      38067510..38080656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001920966.8 → XP_001921001.2  TOX high mobility group box family member 4-A

      UniProtKB/TrEMBL
      A0A8M1QLB8, F1QXS5
      Related
      ENSDARP00000056543.6, ENSDART00000056544.7
      Conserved Domains (2) summary
      PHA03369
      Location:215 → 510
      PHA03369; capsid maturational protease; Provisional
      cd00084
      Location:300 → 365
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394506.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      110376..123522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471257.2 → XP_021326932.1  TOX high mobility group box family member 4-A

      UniProtKB/TrEMBL
      A0A8M1QLB8, F1QXS5
      Conserved Domains (2) summary
      PHA03369
      Location:215 → 510
      PHA03369; capsid maturational protease; Provisional
      cd00084
      Location:300 → 365
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    Nucleotide Protein Strain
    Heading Accession and Version

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