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    stard8 StAR related lipid transfer domain containing 8 [ Danio rerio (zebrafish) ]

    Gene ID: 558476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stard8provided by ZNC
    Official Full Name
    StAR related lipid transfer domain containing 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9447
    See related
    Ensembl:ENSDARG00000014003 AllianceGenome:ZFIN:ZDB-GENE-030131-9447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj78h09; wu:fj78h09; si:ch211-124k10.2
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Predicted to act upstream of or within lipid transport and signal transduction. Is expressed in embryonic structure. Orthologous to human STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See stard8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (35778821..35866174)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (35186046..35266021)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene oligophrenin 1 Neighboring gene Yip1 domain family, member 6 Neighboring gene relaxin family peptide receptor 2, like Neighboring gene STING1 ER exit protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Yang Y, et al. Mol Cell, 2019 Sep 19. PMID 31399345
    2. Evolutionary Origin and Nomenclature of Vertebrate Wnt11-Family Genes. Postlethwait JH, et al. Zebrafish, 2019 Oct. PMID 31295059, Free PMC Article
    3. Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. Pereiro P, et al. Antiviral Res, 2017 Sep. PMID 28789986
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158617

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 8
    Names
    StAR-related lipid transfer (START) domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126477.1 → NP_001119949.1  stAR-related lipid transfer protein 8

      Status: PROVISIONAL

      Source sequence(s)
      BX005476
      UniProtKB/TrEMBL
      A0A8M1NJF9, B0S5B4
      Related
      ENSDARP00000107691.2, ENSDART00000127383.4
      Conserved Domains (3) summary
      cd08907
      Location:863 → 1067
      START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09538
      Location:43 → 102
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cd04375
      Location:621 → 837
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      35778821..35866174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476190.2 → XP_021331865.1  stAR-related lipid transfer protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QE11
      Conserved Domains (3) summary
      cd08907
      Location:850 → 1054
      START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09538
      Location:30 → 89
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cd04375
      Location:608 → 824
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    2. XM_005171885.5 → XP_005171942.1  stAR-related lipid transfer protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJ68
      Conserved Domains (3) summary
      cd08907
      Location:862 → 1066
      START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09538
      Location:43 → 102
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cd04375
      Location:620 → 836
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    3. XM_005171886.4 → XP_005171943.1  stAR-related lipid transfer protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BJQ2
      Conserved Domains (3) summary
      cd08907
      Location:837 → 1041
      START_STARD8-like; C-terminal lipid-binding START domain of mammalian STARD8 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09538
      Location:17 → 76
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      cd04375
      Location:595 → 811
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394592.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      261149..338843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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