myh10 myosin, heavy chain 10, non-muscle [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myh10provided by ZNC
Official Full Name: myosin, heavy chain 10, non-muscleprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-162
See related: Ensembl:ENSDARG00000000103 AllianceGenome:ZFIN:ZDB-GENE-030616-162
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dZ204D19.2; wu:fc46h07; wu:fy19d11; si:dz150i12.3
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within actin filament bundle distribution; midbrain-hindbrain boundary morphogenesis; and regulation of cell shape. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including brain; eye; paraxial mesoderm; swim bladder bud; and tail bud. Orthologous to human MYH10 (myosin heavy chain 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (7553104..7658287)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (7395905..7501116)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

myh10 gene expression was demonstrated to initiate after gastrulation stage; at 20 hpf, expression is mainly restricted in central nervous system; it was maintained and expanded to sensor organ including eye, otic vesicle, and olfactory bulb at 36 hpf and later; also detected myh10 mRNA hybridization signal in 48 hpf heart
Title: Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

AI883936 (e-PCR)
- UniSTS:205961

fi32e03.y1 (e-PCR)
- UniSTS:197285

fc70b05.y1 (e-PCR)
- UniSTS:194298

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament bundle distribution	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: myosin-10

Names: myosin, heavy polypeptide 10, non-muscle; nm-mhc-b; nonmuscle myosin heavy chain B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

7553104..7658287

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302145.4 → XP_009300420.1 myosin-10 isoform X1

UniProtKB/TrEMBL

A0A8M3AT40, A0A8M3BA62

Conserved Domains (8) summary

cd14920
Location:102 → 812

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:90 → 812

Myosin_head; Myosin head (motor domain)

pfam01576
Location:889 → 1969

Myosin_tail_1; Myosin tail

pfam02736
Location:37 → 75

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1705 → 1714

GBP_C; coiled coil [structural motif]

cl19219
Location:1085 → 1170

DUF342; Protein of unknown function (DUF342)

cl20817
Location:1641 → 1734

GBP_C; Guanylate-binding protein, C-terminal domain

cl23720
Location:1528 → 1637

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_009302149.4 → XP_009300424.1 myosin-10 isoform X3

UniProtKB/TrEMBL

A0A8M2BD01, A0A8M3B073, F1R3G4, I3ISA3

Related

ENSDARP00000125918.1, ENSDART00000151114.2

Conserved Domains (8) summary

cd14920
Location:102 → 790

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:90 → 790

Myosin_head; Myosin head (motor domain)

pfam01576
Location:867 → 1947

Myosin_tail_1; Myosin tail

pfam02736
Location:37 → 75

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1683 → 1692

GBP_C; coiled coil [structural motif]

cl19219
Location:1063 → 1148

DUF342; Protein of unknown function (DUF342)

cl20817
Location:1619 → 1712

GBP_C; Guanylate-binding protein, C-terminal domain

cl23720
Location:1506 → 1615

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_009302147.4 → XP_009300422.1 myosin-10 isoform X2

UniProtKB/TrEMBL

A0A8M3AT40, A0A8M3B359

Conserved Domains (8) summary

cd14920
Location:102 → 796

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:90 → 796

Myosin_head; Myosin head (motor domain)

pfam01576
Location:873 → 1953

Myosin_tail_1; Myosin tail

pfam02736
Location:37 → 75

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1689 → 1698

GBP_C; coiled coil [structural motif]

cl19219
Location:1069 → 1154

DUF342; Protein of unknown function (DUF342)

cl20817
Location:1625 → 1718

GBP_C; Guanylate-binding protein, C-terminal domain

cl23720
Location:1512 → 1621

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_677954.10 → XP_683046.6 myosin-10 isoform X4

UniProtKB/TrEMBL

A0A8M2BD01, A0A8N7USR7, I3ISA3

Conserved Domains (8) summary

cd14920
Location:102 → 774

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:90 → 774

Myosin_head; Myosin head (motor domain)

pfam01576
Location:851 → 1931

Myosin_tail_1; Myosin tail

pfam02736
Location:37 → 75

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1667 → 1676

GBP_C; coiled coil [structural motif]

cl19219
Location:1047 → 1132

DUF342; Protein of unknown function (DUF342)

cl20817
Location:1603 → 1696

GBP_C; Guanylate-binding protein, C-terminal domain

cl23720
Location:1490 → 1597

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)