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    bmp4 bone morphogenetic protein 4 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 549788, updated on 4-Jan-2025

    Summary

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    Official Symbol
    bmp4provided by Xenbase
    Official Full Name
    bone morphogenetic protein 4provided by Xenbase
    Primary source
    Xenbase:XB-GENE-483058
    See related
    Ensembl:ENSXETG00000008620 AllianceGenome:Xenbase:XB-GENE-483058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    zyme; DVR-4; bmp-4; bmp2b; ofc11; xbmp4; XBMP-4; bmp2b1; bmp4-a; bmp4-b
    Summary
    Predicted to enable cytokine activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in cardiovascular system; mesenchyme; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See bmp4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (94976275..94982466, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (74068788..74075903, complement)

    Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene FERM domain containing kindlin 2 Neighboring gene DDHD domain containing 1 Neighboring gene uncharacterized LOC116407065 Neighboring gene cornichon family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes. Knöchel S, et al. Mech Dev, 2001 Nov. PMID 11677055
    2. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Rankin SA, et al. Development, 2012 Aug. PMID 22791896, Free PMC Article
    3. Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Puskaric S, et al. Hum Mol Genet, 2010 Dec 1. PMID 20858598, Free PMC Article
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osr1/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.
      Title: Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
    2. work establishes a link between Tbx5, Shox2 and Bmp4 in the pacemaker region of the developing heart
      Title: Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bone morphogenetic protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017034.3 → NP_001017034.2  bone morphogenetic protein 4 precursor

      See identical proteins and their annotated locations for NP_001017034.2

      Status: PROVISIONAL

      Source sequence(s)
      AJ315161
      UniProtKB/TrEMBL
      A0A6I8SK87, A0A803K7E4, Q90YD6
      Related
      ENSXETP00000092603.2, ENSXETT00000104141.2
      Conserved Domains (2) summary
      pfam00688
      Location:40 → 271
      TGFb_propeptide; TGF-beta propeptide
      cl40434
      Location:294 → 400
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      94976275..94982466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012968461.3 → XP_012823915.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_012823915.1

      UniProtKB/TrEMBL
      A0A6I8SK87, A0A803K7E4, Q90YD6
      Conserved Domains (2) summary
      pfam00688
      Location:40 → 271
      TGFb_propeptide; TGF-beta propeptide
      cl40434
      Location:294 → 400
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily

    2. XM_012968460.3 → XP_012823914.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_012823914.1

      UniProtKB/TrEMBL
      A0A6I8SK87, A0A803K7E4, Q90YD6
      Related
      ENSXETP00000119088.1, ENSXETT00000122667.1
      Conserved Domains (2) summary
      pfam00688
      Location:40 → 271
      TGFb_propeptide; TGF-beta propeptide
      cl40434
      Location:294 → 400
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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