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    Zc3h12b zinc finger CCCH-type containing 12B [ Mus musculus (house mouse) ]

    Gene ID: 547176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zc3h12bprovided by MGI
    Official Full Name
    zinc finger CCCH-type containing 12Bprovided by MGI
    Primary source
    MGI:MGI:2442133
    See related
    Ensembl:ENSMUSG00000035045 AllianceGenome:MGI:2442133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm373; CXorf32; A130028J20Rik
    Summary
    Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12B (zinc finger CCCH-type containing 12B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 1.7), cortex adult (RPKM 1.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h12b in Genome Data Viewer
    Location:
    X C3; X 42.14 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94755206..94976262)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95711583..95932656)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene adenylosuccinate lyase pseudogene Neighboring gene predicted gene, 29889 Neighboring gene RIKEN cDNA 1700010D01 gene Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47575 Neighboring gene LAS1-like (S. cerevisiae) Neighboring gene predicted gene, 41897 Neighboring gene eukaryotic translation initiation factor 4B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. Liang J, et al. J Biol Chem, 2008 Mar 7. PMID 18178554
    2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
      Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0615

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ribonuclease ZC3H12B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034907.3 → NP_001030079.2  probable ribonuclease ZC3H12B

      See identical proteins and their annotated locations for NP_001030079.2

      Status: VALIDATED

      Source sequence(s)
      AK134628, AL732438, BX005184
      Consensus CDS
      CCDS41069.1
      UniProtKB/TrEMBL
      G3X9I7
      Related
      ENSMUSP00000080820.7, ENSMUST00000082183.8
      Conserved Domains (4) summary
      cd18729
      Location:192 → 322
      PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
      pfam18039
      Location:107 → 148
      UBA_6; UBA-like domain
      pfam18044
      Location:359 → 377
      zf-CCCH_4; CCCH-type zinc finger
      pfam18561
      Location:795 → 829
      Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      94755206..94976262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247643.4 → XP_011245945.1  probable ribonuclease ZC3H12B isoform X3

      Conserved Domains (3) summary
      cd18729
      Location:192 → 322
      PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
      pfam18039
      Location:107 → 148
      UBA_6; UBA-like domain
      pfam18044
      Location:359 → 377
      zf-CCCH_4; CCCH-type zinc finger

    2. XM_011247641.4 → XP_011245943.1  probable ribonuclease ZC3H12B isoform X1

      See identical proteins and their annotated locations for XP_011245943.1

      UniProtKB/TrEMBL
      G3X9I7
      Conserved Domains (4) summary
      cd18729
      Location:192 → 322
      PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
      pfam18039
      Location:107 → 148
      UBA_6; UBA-like domain
      pfam18044
      Location:359 → 377
      zf-CCCH_4; CCCH-type zinc finger
      pfam18561
      Location:795 → 829
      Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain

    3. XM_011247642.4 → XP_011245944.1  probable ribonuclease ZC3H12B isoform X2

      Conserved Domains (3) summary
      cd18729
      Location:192 → 322
      PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
      pfam18039
      Location:107 → 148
      UBA_6; UBA-like domain
      pfam18044
      Location:359 → 377
      zf-CCCH_4; CCCH-type zinc finger

    4. XM_011247640.2 → XP_011245942.1  probable ribonuclease ZC3H12B isoform X1

      See identical proteins and their annotated locations for XP_011245942.1

      UniProtKB/TrEMBL
      G3X9I7
      Conserved Domains (4) summary
      cd18729
      Location:192 → 322
      PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
      pfam18039
      Location:107 → 148
      UBA_6; UBA-like domain
      pfam18044
      Location:359 → 377
      zf-CCCH_4; CCCH-type zinc finger
      pfam18561
      Location:795 → 829
      Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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