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    CYP2R1 cytochrome P450 family 2 subfamily R member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 541302, updated on 30-Jan-2025

    Summary

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    Official Symbol
    CYP2R1provided by VGNC
    Official Full Name
    cytochrome P450 family 2 subfamily R member 1provided by VGNC
    Primary source
    VGNC:VGNC:110260
    See related
    BGD:BT17385; EnsemblRapid:ENSBTAG00070012947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CYP2R1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (37890019..37915281)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting-associated protein 33A-like Neighboring gene calcitonin-related polypeptide beta Neighboring gene phosphodiesterase 3B Neighboring gene uncharacterized LOC132342325 Neighboring gene uncharacterized LOC132342326

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC140495

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in organic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vitamin D 25-hydroxylase
    Names
    cytochrome P450, family 2, subfamily R, polypeptide 1
    NP_001069735.1
    NP_001421746.1
    NP_001421747.1
    XP_005216114.1
    XP_005216116.1
    XP_024831282.1
    XP_059730932.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076267.3 → NP_001069735.1  vitamin D 25-hydroxylase isoform 3

      See identical proteins and their annotated locations for NP_001069735.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000015
      UniProtKB/TrEMBL
      Q0P5I1
      Related
      ENSBTAP00070017880.1, ENSBTAT00070029319.1
      Conserved Domains (1) summary
      cl12078
      Location:124 → 286
      p450; Cytochrome P450

    2. NM_001434817.1 → NP_001421746.1  vitamin D 25-hydroxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000015
      Related
      ENSBTAP00070017891.1, ENSBTAT00070029347.1

    3. NM_001434818.1 → NP_001421747.1  vitamin D 25-hydroxylase isoform 2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000015

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37890019..37915281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216057.5 → XP_005216114.1  vitamin D 25-hydroxylase isoform X2

      UniProtKB/TrEMBL
      F1MFR3
      Related
      ENSBTAP00070017920.1, ENSBTAT00070029407.1
      Conserved Domains (1) summary
      pfam00067
      Location:97 → 472
      p450; Cytochrome P450

    2. XM_005216059.5 → XP_005216116.1  vitamin D 25-hydroxylase isoform X5

      Conserved Domains (1) summary
      pfam00067
      Location:41 → 415
      p450; Cytochrome P450

    3. XM_059874949.1 → XP_059730932.1  vitamin D 25-hydroxylase isoform X3

      UniProtKB/TrEMBL
      A0AAA9TGV2

    4. XM_024975514.2 → XP_024831282.1  vitamin D 25-hydroxylase isoform X4

      UniProtKB/TrEMBL
      A0AAA9TGV2
      Conserved Domains (1) summary
      pfam00067
      Location:14 → 435
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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