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    BoLA major histocompatibility complex, class I, A [ Bos taurus (domestic cattle) ]

    Gene ID: 533050, updated on 27-Dec-2024

    Summary

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    Gene symbol
    BoLA
    Gene description
    major histocompatibility complex, class I, A
    See related
    BGD:BT24262; Ensembl:ENSBTAG00000020116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HD15; BoLA-NC
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    Genomic context

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    See BoLA in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27829793..27948002)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343675 Neighboring gene interferon-induced transmembrane protein 3-like Neighboring gene microRNA mir-10167 Neighboring gene CD99 molecule Neighboring gene MHC class I heavy chain Neighboring gene BOLA class I histocompatibility antigen, alpha chain BL3-7-like Neighboring gene major histocompatibility class I related protein Neighboring gene MHC class I polypeptide-related sequence B Neighboring gene POU class 5 homeobox 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Evidence for at least three transcribed BoLA class I loci. Garber TL, et al. Immunogenetics, 1994. PMID 8119732
    2. cDNA sequence of cattle MHC class I genes transcribed in serologically defined haplotypes A18 and A31. Ellis SA, et al. Immunogenetics, 1996. PMID 8550100
    3. A novel RNAseq-assisted method for MHC class I genotyping in a non-model species applied to a lethal vaccination-induced alloimmune disease. Demasius W, et al. BMC Genomics, 2016 May 17. PMID 27188848, Free PMC Article
    4. Evidence for expression of both classical and non-classical major histocompatibility complex class I genes in bovine trophoblast cells. Davies CJ, et al. Am J Reprod Immunol, 2006 Mar. PMID 16451353
    5. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142969

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility complex, class I, A
    Names
    MHC class I antigen
    MHC class I heavy chain
    non-MHC class I antigen
    non-classical MHC class I antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114855.1 → NP_001108327.1  major histocompatibility complex, class I, A precursor

      See identical proteins and their annotated locations for NP_001108327.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134573
      UniProtKB/TrEMBL
      A0A173FDN0, A7YWH4
      Conserved Domains (2) summary
      cd07698
      Location:207 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27829793..27948002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880385.1 → XP_059736368.1  major histocompatibility complex, class I, A isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LRW6

    2. XM_059880384.1 → XP_059736367.1  major histocompatibility complex, class I, A isoform X1

      UniProtKB/TrEMBL
      A0A173FDN0, A7YWH4

    3. XM_015459888.3 → XP_015315374.1  major histocompatibility complex, class I, A isoform X2

      UniProtKB/TrEMBL
      A0A173FDN0
      Conserved Domains (3) summary
      cd07698
      Location:207 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:335 → 362
      MHC_I_C; MHC_I C-terminus

    4. XM_015459890.3 → XP_015315376.1  major histocompatibility complex, class I, A isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LRW6
      Conserved Domains (3) summary
      cd07698
      Location:207 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:335 → 362
      MHC_I_C; MHC_I C-terminus

    5. XM_005223701.5 → XP_005223758.1  major histocompatibility complex, class I, A isoform X5

      See identical proteins and their annotated locations for XP_005223758.1

      UniProtKB/TrEMBL
      A0A173FDH2, F1MZQ5
      Related
      ENSBTAP00000016194.7, ENSBTAT00000016194.7

    6. XM_002697329.6 → XP_002697375.1  major histocompatibility complex, class I, A isoform X6

      See identical proteins and their annotated locations for XP_002697375.1

      UniProtKB/TrEMBL
      A6QPT2
    Nucleotide Protein Strain
    Heading Accession and Version

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