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    Il22 interleukin 22 [ Mus musculus (house mouse) ]

    Gene ID: 50929, updated on 27-Nov-2024

    Summary

    Official Symbol
    Il22provided by MGI
    Official Full Name
    interleukin 22provided by MGI
    Primary source
    MGI:MGI:1355307
    See related
    Ensembl:ENSMUSG00000074695 AllianceGenome:MGI:1355307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-22; If2b1; Iltif; IL-22a; ILTIFa
    Summary
    Enables cytokine activity. Involved in negative regulation of inflammatory response. Acts upstream of or within positive regulation of transcription by RNA polymerase II; reactive oxygen species metabolic process; and regulation of tyrosine phosphorylation of STAT protein. Is active in extracellular space. Is expressed in ileum; retina; and skin. Used to study liposarcoma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL22 (interleukin 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 2.3), large intestine adult (RPKM 0.5) and 2 other tissues See more
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    Genomic context

    See Il22 in Genome Data Viewer
    Location:
    10 D2; 10 66.67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (118040456..118045952)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (118204584..118210047)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2341 Neighboring gene MDM1 nuclear protein Neighboring gene predicted gene, 40775 Neighboring gene LIM domain kinase 1, pseudogene 1 Neighboring gene cell division cycle 5 like, retrotransposed 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (10)  1 citation

    General gene information

    General protein information

    Preferred Names
    interleukin-22
    Names
    IL-10-related T-cell-derived-inducible factor
    IL-TIF alpha
    ILTIF alpha
    interferon 2b1
    interleukin 10-related T cell-derived inducible factor
    interleukin-22a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016971.2NP_058667.1  interleukin-22 precursor

      See identical proteins and their annotated locations for NP_058667.1

      Status: VALIDATED

      Source sequence(s)
      AC153856
      Consensus CDS
      CCDS36070.1
      UniProtKB/Swiss-Prot
      Q14BB3, Q9JJY9
      UniProtKB/TrEMBL
      Q3SXE1
      Related
      ENSMUSP00000094449.5, ENSMUST00000096691.5
      Conserved Domains (1) summary
      cl02501
      Location:40178
      IL10; Interleukin 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      118040456..118045952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513865.4XP_006513928.1  interleukin-22 isoform X1

      See identical proteins and their annotated locations for XP_006513928.1

      UniProtKB/Swiss-Prot
      Q14BB3, Q9JJY9
      UniProtKB/TrEMBL
      Q3SXE1
      Conserved Domains (1) summary
      cl02501
      Location:40178
      IL10; Interleukin 10