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    lepA translation elongation factor 4 [ Staphylococcus epidermidis ]

    Gene ID: 50018613, updated on 3-Dec-2024

    Summary

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    Gene symbol
    lepA
    Gene description
    translation elongation factor 4
    Locus tag
    EQW00_RS06325
    Gene type
    protein coding
    Organism
    Staphylococcus epidermidis (strain: ATCC 14990, culture-collection: ATCC:14990, type-material: type strain of Staphylococcus epidermidis)
    Lineage
    Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus
    Old locus tag
    EQW00_06330
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    Genomic context

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    NZ_CP035288.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase III subunit delta Neighboring gene 30S ribosomal protein S20 Neighboring gene radical SAM family heme chaperone HemW Neighboring gene heat-inducible transcriptional repressor HrcA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_CP035288.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combined antibiotic stewardship and infection control measures to contain the spread of linezolid-resistant Staphylococcus epidermidis in an intensive care unit. Papan C, et al. Antimicrob Resist Infect Control, 2021 Jun 30. PMID 34193293, Free PMC Article
    2. EF4 reveals the energy barrier for tRNA back-translocation in the peptidyl transferase center. Song G, et al. RNA Biol, 2016 Oct 2. PMID 27472653, Free PMC Article
    3. Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome. Kumar V, et al. J Biol Chem, 2016 Jun 17. PMID 27137929, Free PMC Article
    4. The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis. Liu H, et al. Proc Natl Acad Sci U S A, 2011 Sep 27. PMID 21930951, Free PMC Article
    5. Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis of the 30S subunit of the 70S ribosome. Gibbs MR, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096346, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    translation elongation factor 4
    WP_001831284.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_CP035288.1 Reference assembly

      Range
      1277020..1278843
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_001831284.1 MULTISPECIES: translation elongation factor 4 [Staphylococcus]

      See identical proteins and their annotated locations for WP_001831284.1

      UniProtKB/Swiss-Prot
      Q5HNW2, Q8CP13
      UniProtKB/TrEMBL
      A0A0N1ELV9, A0A9Q5JLH9
      Conserved Domains (1) summary
      PRK05433
      Location:9 → 607
      PRK05433; GTP-binding protein LepA; Provisional
    Nucleotide Protein
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