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    Uckl1 uridine-cytidine kinase 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uckl1provided by RGD
    Official Full Name
    uridine-cytidine kinase 1-like 1provided by RGD
    Primary source
    RGD:1565465
    See related
    EnsemblRapid:ENSRNOG00000050277 AllianceGenome:RGD:1565465
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565465
    Summary
    Predicted to enable ATP binding activity and uridine kinase activity. Predicted to be involved in CTP salvage; UMP salvage; and phosphorylation. Predicted to be active in cytoplasm. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 90.0), Thymus (RPKM 56.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uckl1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189052365..189064939, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168674849..168687513, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177066022..177078611, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548047 Neighboring gene TPD52 like 2 Neighboring gene ribosomal protein L34-like2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene zinc finger protein 512B Neighboring gene sterile alpha motif domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uridine-cytidine kinase-like 1
    NP_001102682.1
    XP_006235855.1
    XP_006235856.1
    XP_006235857.1
    XP_006235858.1
    XP_038961641.1
    XP_038961642.1
    XP_038961643.1
    XP_038961645.1
    XP_038961646.1
    XP_038961647.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109212.1 → NP_001102682.1  uridine-cytidine kinase-like 1

      See identical proteins and their annotated locations for NP_001102682.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474066
      UniProtKB/TrEMBL
      A6KLZ1, D3ZYQ8
      Related
      ENSRNOP00000020695.6, ENSRNOT00000020695.8
      Conserved Domains (2) summary
      cd02023
      Location:101 → 299
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:329 → 532
      UPRTase; Uracil phosphoribosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      189052365..189064939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105713.2 → XP_038961641.1  uridine-cytidine kinase-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GA89, D3ZYQ8
      Related
      ENSRNOP00000084349.1, ENSRNOT00000112230.2
      Conserved Domains (2) summary
      cd02023
      Location:101 → 299
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:330 → 533
      UPRTase; Uracil phosphoribosyltransferase

    2. XM_039105714.2 → XP_038961642.1  uridine-cytidine kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      D3ZYQ8
      Conserved Domains (2) summary
      cd02023
      Location:100 → 298
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:329 → 532
      UPRTase; Uracil phosphoribosyltransferase

    3. XM_039105715.2 → XP_038961643.1  uridine-cytidine kinase-like 1 isoform X3

      UniProtKB/TrEMBL
      D3ZYQ8
      Related
      ENSRNOP00000094809.2, ENSRNOT00000113965.2
      Conserved Domains (2) summary
      cd02023
      Location:100 → 298
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:328 → 531
      UPRTase; Uracil phosphoribosyltransferase

    4. XM_006235795.5 → XP_006235857.1  uridine-cytidine kinase-like 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVU1
      Conserved Domains (2) summary
      cd02023
      Location:85 → 283
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:314 → 517
      UPRTase; Uracil phosphoribosyltransferase

    5. XM_039105717.2 → XP_038961645.1  uridine-cytidine kinase-like 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZVU1
      Conserved Domains (2) summary
      cd02023
      Location:85 → 283
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:313 → 516
      UPRTase; Uracil phosphoribosyltransferase

    6. XM_006235793.5 → XP_006235855.1  uridine-cytidine kinase-like 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVU1, A0A8I6AIR8
      Conserved Domains (3) summary
      COG0572
      Location:78 → 291
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:86 → 284
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:315 → 518
      UPRTase; Uracil phosphoribosyltransferase

    7. XM_006235794.5 → XP_006235856.1  uridine-cytidine kinase-like 1 isoform X5

      See identical proteins and their annotated locations for XP_006235856.1

      UniProtKB/TrEMBL
      A0A8I5Y757, A0A8I5ZVU1, A6KLZ3
      Conserved Domains (2) summary
      cd02023
      Location:86 → 284
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:314 → 517
      UPRTase; Uracil phosphoribosyltransferase

    8. XM_006235796.5 → XP_006235858.1  uridine-cytidine kinase-like 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GJU6
      Conserved Domains (3) summary
      COG0572
      Location:57 → 270
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:65 → 263
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
      pfam14681
      Location:294 → 497
      UPRTase; Uracil phosphoribosyltransferase

    9. XM_039105719.2 → XP_038961647.1  uridine-cytidine kinase-like 1 isoform X10

      Conserved Domains (1) summary
      cd02023
      Location:101 → 299
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    10. XM_039105718.2 → XP_038961646.1  uridine-cytidine kinase-like 1 isoform X9

      Conserved Domains (1) summary
      cd02023
      Location:101 → 299
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    RNA

    1. XR_005501969.2 RNA Sequence

    2. XR_010064686.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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